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Mendeley readers
Attention Score in Context
| Title |
The Runx transcriptional co-activator, CBFβ, is essential for invasion of breast cancer cells
|
|---|---|
| Published in |
Molecular Cancer, June 2010
|
| DOI | 10.1186/1476-4598-9-171 |
| Pubmed ID | |
| Authors |
Daniel Mendoza-Villanueva, Wensheng Deng, Cesar Lopez-Camacho, Paul Shore |
| Abstract |
The transcription factor Runx2 has an established role in cancers that metastasize to bone. In metastatic breast cancer cells Runx2 is overexpressed and contributes to the invasive capacity of the cells by regulating the expression of several invasion genes. CBFbeta is a transcriptional co-activator that is recruited to promoters by Runx transcription factors and there is considerable evidence that CBFbeta is essential for the function of Runx factors. However, overexpression of Runx1 can partially rescue the lethal phenotype in CBFbeta-deficient mice, indicating that increased levels of Runx factors can, in some situations, overcome the requirement for CBFbeta. Since Runx2 is overexpressed in metastatic breast cancer cells, and there are no reports of CBFbeta expression in breast cells, we sought to determine whether Runx2 function in these cells was dependent on CBFbeta. Such an interaction might represent a viable target for therapeutic intervention to inhibit bone metastasis. |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 3% |
| Unknown | 76 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 26% |
| Student > Bachelor | 14 | 18% |
| Researcher | 11 | 14% |
| Student > Master | 10 | 13% |
| Student > Doctoral Student | 4 | 5% |
| Other | 5 | 6% |
| Unknown | 14 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 35 | 45% |
| Biochemistry, Genetics and Molecular Biology | 17 | 22% |
| Medicine and Dentistry | 8 | 10% |
| Immunology and Microbiology | 2 | 3% |
| Psychology | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 14 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2015.
All research outputs
#5,864,825
of 22,778,347 outputs
Outputs from Molecular Cancer
#400
of 1,719 outputs
Outputs of similar age
#27,376
of 93,114 outputs
Outputs of similar age from Molecular Cancer
#9
of 25 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,719 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,114 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.