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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Development of a Concise Synthesis of Ouabagenin and Hydroxylated Corticosteroid Analogues
|
|---|---|
| Published in |
Journal of the American Chemical Society, January 2015
|
| DOI | 10.1021/ja512022r |
| Pubmed ID | |
| Authors |
Hans Renata, Qianghui Zhou, Georg Dünstl, Jakob Felding, Rohan R. Merchant, Chien-Hung Yeh, Phil S. Baran |
| Abstract |
The natural product ouabagenin is a complex cardiotonic steroid with a highly oxygenated skeleton. This full account describes the development of a concise synthesis of ouabagenin, including the evolution of synthetic strategy to access hydroxylation at the C19 position of a steroid skeleton. In addition, approaches to install the requisite butenolide moiety at the C17 position are discussed. Lastly, methodology developed in this synthesis has been applied in the generation of novel analogues of corticosteroid drugs bearing a hydroxyl group at the C19 position. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 29% |
| Mexico | 1 | 14% |
| Spain | 1 | 14% |
| Japan | 1 | 14% |
| United Kingdom | 1 | 14% |
| Unknown | 1 | 14% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 57% |
| Members of the public | 3 | 43% |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 2% |
| Unknown | 109 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 22% |
| Researcher | 18 | 16% |
| Student > Master | 12 | 11% |
| Student > Bachelor | 10 | 9% |
| Student > Doctoral Student | 7 | 6% |
| Other | 19 | 17% |
| Unknown | 21 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 80 | 72% |
| Medicine and Dentistry | 2 | 2% |
| Computer Science | 2 | 2% |
| Chemical Engineering | 1 | <1% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | <1% |
| Other | 2 | 2% |
| Unknown | 23 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2020.
All research outputs
#6,227,307
of 22,778,347 outputs
Outputs from Journal of the American Chemical Society
#25,486
of 61,949 outputs
Outputs of similar age
#85,476
of 352,360 outputs
Outputs of similar age from Journal of the American Chemical Society
#179
of 504 outputs
Altmetric has tracked 22,778,347 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 61,949 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 58% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,360 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 504 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.