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Sprouty2 mediated tuning of signalling is essential for somite myogenesis

Overview of attention for article published in BMC Medical Genomics, January 2015
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (59th percentile)

Mentioned by

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2 tweeters

Citations

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1 Dimensions

Readers on

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13 Mendeley
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Title
Sprouty2 mediated tuning of signalling is essential for somite myogenesis
Published in
BMC Medical Genomics, January 2015
DOI 10.1186/1755-8794-8-s1-s8
Pubmed ID
Authors

Abu-Elmagd, Muhammad, Goljanek Whysall, Katarzyna, Wheeler, Grant, Münsterberg, Andrea, Abu-Elmagd M, Goljanek Whysall K, Wheeler G, Münsterberg A

Abstract

Negative regulators of signal transduction cascades play critical roles in controlling different aspects of normal embryonic development. Sprouty2 (Spry2) negatively regulates receptor tyrosine kinases (RTK) and FGF signalling and is important in differentiation, cell migration and proliferation. In vertebrate embryos, Spry2 is expressed in paraxial mesoderm and in forming somites. Expression is maintained in the myotome until late stages of somite differentiation. However, its role and mode of action during somite myogenesis is still unclear. Here, we analysed chick Spry2 expression and showed that it overlaps with that of myogenic regulatory factors MyoD and Mgn. Targeted mis-expression of Spry2 led to inhibition of myogenesis, whilst its C-terminal domain led to an increased number of myogenic cells by stimulating cell proliferation. Spry2 is expressed in somite myotomes and its expression overlaps with myogenic regulatory factors. Overexpression and dominant-negative interference showed that Spry2 plays a crucial role in regulating chick myogenesis by fine tuning of FGF signaling through a negative feedback loop. We also propose that mir-23, mir-27 and mir-128 could be part of the negative feedback loop mechanism. Our analysis is the first to shed some light on in vivo Spry2 function during chick somite myogenesis.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 31%
Student > Bachelor 3 23%
Professor > Associate Professor 2 15%
Researcher 2 15%
Unknown 2 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 54%
Biochemistry, Genetics and Molecular Biology 4 31%
Unknown 2 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 March 2015.
All research outputs
#2,085,376
of 4,833,230 outputs
Outputs from BMC Medical Genomics
#157
of 334 outputs
Outputs of similar age
#65,872
of 169,302 outputs
Outputs of similar age from BMC Medical Genomics
#16
of 19 outputs
Altmetric has tracked 4,833,230 research outputs across all sources so far. This one has received more attention than most of these and is in the 55th percentile.
So far Altmetric has tracked 334 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 169,302 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.