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Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis

Overview of attention for article published in Scientific Reports, May 2017
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2 tweeters

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3 Dimensions

Readers on

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26 Mendeley
Title
Misoprostol for medical treatment of missed abortion: a systematic review and network meta-analysis
Published in
Scientific Reports, May 2017
DOI 10.1038/s41598-017-01892-0
Pubmed ID
Authors

Hang-lin Wu, Sheeba Marwah, Pei Wang, Qiu-meng Wang, Xiao-wen Chen

Abstract

The efficacy and safety of misoprostol alone for missed abortion varied with different regimens. To evaluate existing evidence for the medical management of missed abortion using misoprostol, we undertook a comprehensive review and meta-analysis. The electronic literature search was conducted using PubMed, the Cochrane Library, Embase, EBSCOhost Online Research Databases, Springer Link, ScienceDirect, Web of Science, Ovid Medline and Google Scholar. 18 studies of 1802 participants were included in our analysis. Compared with vaginal misoprostol of 800 ug or sublingual misoprostol of 600 ug, lower-dose regimens (200 ug or 400 ug) by any route of administration tend to be significantly less effective in producing abortion within about 24 hours. In terms of efficacy, the most effective treatment was sublingual misoprostol of 600 ug and the least effective was oral misoprostol of 400 ug. In terms of tolerability, vaginal misoprostol of 400 ug was reported with fewer side effects and sublingual misoprostol of 600 ug was reported with more side effects. Misoprostol is a non-invasive, effective medical method for completion of abortion in missed abortion. Sublingual misoprostol of 600 ug or vaginal misoprostol of 800 ug may be a good choice for the first dose. The ideal dose and medication interval of misoprostol however needs to be further researched.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 26 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 7 27%
Unspecified 4 15%
Student > Bachelor 4 15%
Student > Master 4 15%
Other 3 12%
Other 4 15%
Readers by discipline Count As %
Medicine and Dentistry 15 58%
Unspecified 5 19%
Nursing and Health Professions 2 8%
Immunology and Microbiology 1 4%
Agricultural and Biological Sciences 1 4%
Other 2 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2019.
All research outputs
#7,520,747
of 13,047,582 outputs
Outputs from Scientific Reports
#30,853
of 61,946 outputs
Outputs of similar age
#184,126
of 382,671 outputs
Outputs of similar age from Scientific Reports
#6,002
of 12,921 outputs
Altmetric has tracked 13,047,582 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 61,946 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.4. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 382,671 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12,921 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.