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Biomechanical properties of 3D-printed bone scaffolds are improved by treatment with CRFP

Overview of attention for article published in Journal of Orthopaedic Surgery and Research, December 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#14 of 873)
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
1 news outlet
twitter
6 tweeters
patent
1 patent

Citations

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5 Dimensions

Readers on

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28 Mendeley
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Title
Biomechanical properties of 3D-printed bone scaffolds are improved by treatment with CRFP
Published in
Journal of Orthopaedic Surgery and Research, December 2017
DOI 10.1186/s13018-017-0700-2
Pubmed ID
Authors

Carlos G. Helguero, Vamiq M. Mustahsan, Sunjit Parmar, Sahana Pentyala, John L. Pfail, Imin Kao, David E. Komatsu, Srinivas Pentyala

Abstract

One of the major challenges in orthopedics is to develop implants that overcome current postoperative problems such as osteointegration, proper load bearing, and stress shielding. Current implant techniques such as allografts or endoprostheses never reach full bone integration, and the risk of fracture due to stress shielding is a major concern. To overcome this, a novel technique of reverse engineering to create artificial scaffolds was designed and tested. The purpose of the study is to create a new generation of implants that are both biocompatible and biomimetic. 3D-printed scaffolds based on physiological trabecular bone patterning were printed. MC3T3 cells were cultured on these scaffolds in osteogenic media, with and without the addition of Calcitonin Receptor Fragment Peptide (CRFP) in order to assess bone formation on the surfaces of the scaffolds. Integrity of these cell-seeded bone-coated scaffolds was tested for their mechanical strength. The results show that cellular proliferation and bone matrix formation are both supported by our 3D-printed scaffolds. The mechanical strength of the scaffolds was enhanced by trabecular patterning in the order of 20% for compression strength and 60% for compressive modulus. Furthermore, cell-seeded trabecular scaffolds modulus increased fourfold when treated with CRFP. Upon mineralization, the cell-seeded trabecular implants treated with osteo-inductive agents and pretreated with CRFP showed a significant increase in the compressive modulus. This work will lead to creating 3D structures that can be used in the replacement of not only bone segments, but entire bones.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 18%
Researcher 4 14%
Student > Master 4 14%
Student > Postgraduate 2 7%
Student > Bachelor 2 7%
Other 3 11%
Unknown 8 29%
Readers by discipline Count As %
Medicine and Dentistry 7 25%
Engineering 6 21%
Agricultural and Biological Sciences 1 4%
Materials Science 1 4%
Mathematics 1 4%
Other 0 0%
Unknown 12 43%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2020.
All research outputs
#1,243,654
of 15,392,253 outputs
Outputs from Journal of Orthopaedic Surgery and Research
#14
of 873 outputs
Outputs of similar age
#48,007
of 406,355 outputs
Outputs of similar age from Journal of Orthopaedic Surgery and Research
#3
of 138 outputs
Altmetric has tracked 15,392,253 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 873 research outputs from this source. They receive a mean Attention Score of 2.2. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 406,355 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 138 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.