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Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol

Overview of attention for article published in Jornal de Pediatria, January 2019
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Title
Treatment adherence and level of control in moderate persistent asthma in children and adolescents treated with fluticasone and salmeterol
Published in
Jornal de Pediatria, January 2019
DOI 10.1016/j.jped.2017.10.008
Pubmed ID
Authors

Nulma S. Jentzsch, Gabriela C.G. Silva, Guilherme M.S. Mendes, Paul L.P. Brand, Paulo Camargos

Abstract

There is a scarcity of studies that assessed the association between adherence to combination therapy and asthma control in pediatric patients. The authors investigated the association between adherence to fluticasone propionate/salmeterol xinafoate combination-pMDI and the level of asthma control in children. This was a prospective observational study of 84 patients aged 5-16 years with moderate persistent asthma, who remained uncontrolled despite the use of 1000μg/day of inhaled nonextrafine-HFA-beclomethasone dipropionate in the three months prior to study enrollment. Participants were prescribed two daily doses of FP (125μg)/salmeterol xinafoate (25μg) combination by pMDI/spacer for six months. Adherence rates were assessed using the device's dose counter after the 2nd, 4th, and 6th months of follow up. Asthma control was assessed using a simplified Global Initiative for Asthma 2014 Report classification. Mean adherence rates after the second, fourth, and sixth months were 87.8%, 74.9%, and 62.1% respectively, for controlled asthma, and 71.7%, 56.0%, and 47.6% respectively, for uncontrolled asthma (all p-values≤0.03). The proportion of children achieving asthma control increased to 42.9%, 67.9% and 89.3% after the 2nd, 4th and 6th months of follow-up, respectively (p≤0.001). Adherence rates between 87.8% in the 2nd month and 62.1% in the 6th month were strong determinants of asthma control.

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Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 4 18%
Student > Master 4 18%
Student > Postgraduate 3 14%
Professor 2 9%
Researcher 2 9%
Other 4 18%
Unknown 3 14%
Readers by discipline Count As %
Medicine and Dentistry 7 32%
Nursing and Health Professions 6 27%
Biochemistry, Genetics and Molecular Biology 3 14%
Immunology and Microbiology 1 5%
Pharmacology, Toxicology and Pharmaceutical Science 1 5%
Other 0 0%
Unknown 4 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2017.
All research outputs
#11,059,162
of 12,440,542 outputs
Outputs from Jornal de Pediatria
#318
of 417 outputs
Outputs of similar age
#303,192
of 361,120 outputs
Outputs of similar age from Jornal de Pediatria
#6
of 8 outputs
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So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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