↓ Skip to main content

Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells

Overview of attention for article published in Cancer Research, March 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

twitter
4 X users
facebook
1 Facebook page
wikipedia
1 Wikipedia page
f1000
1 research highlight platform

Citations

dimensions_citation
320 Dimensions

Readers on

mendeley
308 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells
Published in
Cancer Research, March 2015
DOI 10.1158/0008-5472.can-14-2613
Pubmed ID
Authors

Laure Cayrefourcq, Thibault Mazard, Simon Joosse, Jérôme Solassol, Jeanne Ramos, Eric Assenat, Udo Schumacher, Valérie Costes, Thierry Maudelonde, Klaus Pantel, Catherine Alix-Panabières

Abstract

Circulating tumor cells (CTCs) in blood are promising new biomarkers potentially useful for prognostic prediction and monitoring of therapies in patients with solid tumors including colon cancer. Moreover, CTC research opens a new avenue for understanding the biology of metastasis in cancer patients. However, an in-depth investigation of CTCs is hampered by the very low number of these cells, especially in the blood of colorectal cancer patients. Thus, the establishment of cell cultures and permanent cell lines from CTCs has become the most challenging task over the past year. Here we describe, for the first time, the establishment of cell cultures and a permanent cell line from CTCs of one colon cancer patient. The cell line designated CTC-MCC-41 has been cultured for more than one year and the cells have been characterized at the genome, transcriptome, proteome and secretome levels. This thorough analysis showed that CTC-MCC-41 cells resemble characteristics of the original tumor cells in the colon cancer patient and display a stable phenotype characterized by an intermediate epithelial/mesenchymal phenotype, stem-cell like properties and an osteomimetic signature indicating a bone marrow origin. Functional studies showed that CTC-MCC-41 cells induced rapidly in vitro endothelial cell tube formation and in vivo tumors after xenografting in immunodeficient mice. The establishment of this first colon cancer CTC line allows now a wealth of functional studies on the biology of CTCs as well as in vitro and in vivo drug testing.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 308 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
France 2 <1%
Germany 1 <1%
Malaysia 1 <1%
Japan 1 <1%
Italy 1 <1%
Unknown 299 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 65 21%
Student > Ph. D. Student 56 18%
Student > Bachelor 26 8%
Student > Master 24 8%
Student > Doctoral Student 22 7%
Other 45 15%
Unknown 70 23%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 64 21%
Medicine and Dentistry 61 20%
Agricultural and Biological Sciences 54 18%
Engineering 21 7%
Chemistry 10 3%
Other 23 7%
Unknown 75 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2023.
All research outputs
#5,177,636
of 24,835,862 outputs
Outputs from Cancer Research
#4,995
of 18,980 outputs
Outputs of similar age
#58,748
of 261,758 outputs
Outputs of similar age from Cancer Research
#36
of 133 outputs
Altmetric has tracked 24,835,862 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 18,980 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.3. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 261,758 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 133 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.