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Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.

Overview of attention for article published in Memórias do Instituto Oswaldo Cruz, February 2015
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2 tweeters

Citations

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35 Dimensions

Readers on

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88 Mendeley
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Title
Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.
Published in
Memórias do Instituto Oswaldo Cruz, February 2015
DOI 10.1590/0074-02760140243
Pubmed ID
Authors

Fernanda Fraga Campos, Policarpo A Sales Junior, Alvaro José Romanha, Márcio SS Araújo, Ezequias P Siqueira, Jarbas M Resende, Tânia MA Alves, Olindo A Martins-Filho, Vera Lúcia dos Santos, Carlos A Rosa, Carlos L Zani, Betania Barros Cota

Abstract

Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and Escherichia coli [minimal inhibitory concentration (MIC) 32-64 μg/mL]. One isolate inhibited the growth of Salmonella typhimurium (MIC 64 μg/mL) and two isolates inhibited the growth of Klebsiella oxytoca (MIC 64 μg/mL), Candida albicans and Candida tropicalis (MIC 64-128 μg/mL). Fourteen extracts at a concentration of 20 μg/mL showed antitumour activities against human breast cancer and human renal cancer cells, while two isolates showed anti-tumour activities against human melanoma cancer cells. Six extracts were able to reduce the proliferation of human peripheral blood mononuclear cells, indicating some degree of selective toxicity. Four isolates were able to inhibit Leishmania (Leishmania) amazonensis and one isolate inhibited Trypanosoma cruzi by at least 40% at 20 μg/mL. The trypanocidal extract obtained from Fusarium sp. [KF611679] culture was subjected to bioguided fractionation, which revealed beauvericin as the compound responsible for the observed toxicity of Fusarium sp. to T. cruzi. This depsipeptide showed a half maximal inhibitory concentration of 1.9 μg/mL (2.43 μM) in a T. cruzi cellular culture assay.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 88 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 2%
Unknown 86 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 17%
Student > Master 14 16%
Researcher 10 11%
Student > Bachelor 7 8%
Student > Doctoral Student 6 7%
Other 20 23%
Unknown 16 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 28%
Biochemistry, Genetics and Molecular Biology 12 14%
Chemistry 9 10%
Medicine and Dentistry 6 7%
Immunology and Microbiology 4 5%
Other 15 17%
Unknown 17 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 September 2015.
All research outputs
#7,544,821
of 12,511,869 outputs
Outputs from Memórias do Instituto Oswaldo Cruz
#561
of 862 outputs
Outputs of similar age
#127,872
of 270,680 outputs
Outputs of similar age from Memórias do Instituto Oswaldo Cruz
#2
of 9 outputs
Altmetric has tracked 12,511,869 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 862 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,680 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.