Title |
Percutaneous Sampling of Local Biomolecule Gradients Across Coronary Artery Atherosclerotic Plaques
|
---|---|
Published in |
JACC: Basic to Translational Science, December 2017
|
DOI | 10.1016/j.jacbts.2017.07.007 |
Pubmed ID | |
Authors |
Nick E.J. West, Joseph P. Corrigan, Richard H.G. Owen, Stephen P. Hoole, Adam J. Brown, Stephen Blatcher, Andrew C. Newby |
Abstract |
A percutaneous catheter device, the Liquid Biopsy System, was developed to sample the unstirred boundary layer of blood upstream and downstream of intact and disrupted human coronary atherosclerotic plaques. Using multiplexed proximity extension assays, release of 20 biomolecules was simultaneously detected in samples taken across plaques before balloon angioplasty, including the soluble form of the endothelial lectin-like oxidized LDL receptor. Additional biomolecules, including matrix metalloproteinase-12, were released after plaque disruption with angioplasty. These experiments demonstrate the power of the Liquid Biopsy System to yield new scientific insights and its ultimate potential to generate new biomarkers and surrogate endpoints for clinical trials. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 12% |
Mexico | 2 | 12% |
United Kingdom | 1 | 6% |
Australia | 1 | 6% |
Canada | 1 | 6% |
Russia | 1 | 6% |
China | 1 | 6% |
Thailand | 1 | 6% |
Colombia | 1 | 6% |
Other | 2 | 12% |
Unknown | 4 | 24% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 47% |
Practitioners (doctors, other healthcare professionals) | 4 | 24% |
Scientists | 3 | 18% |
Science communicators (journalists, bloggers, editors) | 2 | 12% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 27% |
Student > Doctoral Student | 2 | 9% |
Researcher | 2 | 9% |
Student > Master | 2 | 9% |
Other | 1 | 5% |
Other | 4 | 18% |
Unknown | 5 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 36% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Agricultural and Biological Sciences | 1 | 5% |
Immunology and Microbiology | 1 | 5% |
Computer Science | 1 | 5% |
Other | 2 | 9% |
Unknown | 7 | 32% |