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Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications

Overview of attention for article published in International Journal of Nanomedicine, January 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (74th percentile)
  • High Attention Score compared to outputs of the same age and source (89th percentile)

Mentioned by

twitter
4 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
74 Dimensions

Readers on

mendeley
141 Mendeley
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Title
Antibiotic and chemotherapeutic enhanced three-dimensional printer filaments and constructs for biomedical applications
Published in
International Journal of Nanomedicine, January 2015
DOI 10.2147/ijn.s74811
Pubmed ID
Authors

David Mills, Jeffery Weisman, Connor Nicholson, UdayaBhanu Jammalamadaka, Karthik Tappa, Chester Wilson

Abstract

Three-dimensional (3D) printing and additive manufacturing holds potential for highly personalized medicine, and its introduction into clinical medicine will have many implications for patient care. This paper demonstrates the first application of 3D printing as a method for the potential sustained delivery of antibiotic and chemotherapeutic drugs from constructs for patient treatment. Our design is focused on the on-demand production of anti-infective and chemotherapeutic filaments that can be used to create discs, beads, catheters, or any medical construct using a 3D printing system. The design parameters for this project were to create a system that could be modularly loaded with bioactive agents. All 3D-printed constructs were loaded with either gentamicin or methotrexate and were optimized for efficient and extended antibacterial and cancer growth-inhibiting cytostatic activity. Preliminary results demonstrate that combining gentamicin and methotrexate with polylactic acid forms a composite possessing a superior combination of strength, versatility, and enhanced drug delivery. Antibacterial effects and a reduction in proliferation of osteosarcoma cells were observed with all constructs, attesting to the technical and clinical viability of our composites. In this study, 3D constructs were loaded with gentamicin and methotrexate, but the method can be extended to many other drugs. This method could permit clinicians to provide customized and tailored treatment that allows patient-specific treatment of disease and has significant potential for use as a tunable drug delivery system with sustained-release capacity for an array of biomedical applications.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 141 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Greece 1 <1%
Ireland 1 <1%
France 1 <1%
Unknown 138 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 17%
Student > Master 19 13%
Student > Bachelor 16 11%
Researcher 16 11%
Student > Doctoral Student 10 7%
Other 26 18%
Unknown 30 21%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 27 19%
Engineering 26 18%
Medicine and Dentistry 14 10%
Materials Science 9 6%
Chemistry 8 6%
Other 22 16%
Unknown 35 25%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 November 2016.
All research outputs
#3,289,523
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#305
of 2,456 outputs
Outputs of similar age
#68,330
of 266,957 outputs
Outputs of similar age from International Journal of Nanomedicine
#5
of 47 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 47 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.