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X Demographics
Mendeley readers
Attention Score in Context
| Title |
AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation
|
|---|---|
| Published in |
Nature, January 2018
|
| DOI | 10.1038/nature25174 |
| Pubmed ID | |
| Authors |
Martina M. Yordanova, Gary Loughran, Alexander V. Zhdanov, Marco Mariotti, Stephen J. Kiniry, Patrick B. F. O’Connor, Dmitry E. Andreev, Ioanna Tzani, Paul Saffert, Audrey M. Michel, Vadim N. Gladyshev, Dmitry B. Papkovsky, John F. Atkins, Pavel V. Baranov |
| Abstract |
In addition to acting as template for protein synthesis, messenger RNA (mRNA) often contains sensory sequence elements that regulate this process. Here we report a new mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding adenosylmethionine decarboxylase 1 (AdoMetDC). A small proportion of ribosomes translating AMD1 mRNA stochastically read through the stop codon of the main coding region. These readthrough ribosomes then stall close to the next in-frame stop codon, eventually forming a ribosome queue, the length of which is proportional to the number of AdoMetDC molecules that were synthesized from the same AMD1 mRNA. Once the entire spacer region between the two stop codons is filled with queueing ribosomes, the queue impinges upon the main AMD1 coding region halting its translation. Phylogenetic analysis suggests that this mechanism is highly conserved in vertebrates and existed in their common ancestor. We propose that this mechanism is used to count and limit the number of protein molecules that can be synthesized from a single mRNA template. It could serve to safeguard from dysregulated translation that may occur owing to errors in transcription or mRNA damage. |
X Demographics
The data shown below were collected from the profiles of 134 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 37 | 28% |
| United Kingdom | 10 | 7% |
| Ireland | 9 | 7% |
| Canada | 7 | 5% |
| Germany | 5 | 4% |
| Japan | 4 | 3% |
| Switzerland | 3 | 2% |
| Spain | 3 | 2% |
| France | 3 | 2% |
| Other | 16 | 12% |
| Unknown | 37 | 28% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 66 | 49% |
| Members of the public | 62 | 46% |
| Practitioners (doctors, other healthcare professionals) | 5 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 304 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 304 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 76 | 25% |
| Researcher | 62 | 20% |
| Student > Master | 36 | 12% |
| Student > Bachelor | 29 | 10% |
| Student > Doctoral Student | 12 | 4% |
| Other | 33 | 11% |
| Unknown | 56 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 122 | 40% |
| Agricultural and Biological Sciences | 73 | 24% |
| Neuroscience | 9 | 3% |
| Chemistry | 9 | 3% |
| Immunology and Microbiology | 6 | 2% |
| Other | 20 | 7% |
| Unknown | 65 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 121. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2023.
All research outputs
#349,407
of 25,698,912 outputs
Outputs from Nature
#18,103
of 98,553 outputs
Outputs of similar age
#7,875
of 452,450 outputs
Outputs of similar age from Nature
#329
of 804 outputs
Altmetric has tracked 25,698,912 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,553 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,450 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 804 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.