Title |
Understanding the colon cancer stem cells and perspectives on treatment
|
---|---|
Published in |
Cancer Cell International, January 2015
|
DOI | 10.1186/s12935-015-0163-7 |
Pubmed ID | |
Authors |
Elsa N Garza-Treviño, Salvador L Said-Fernández, Herminia G Martínez-Rodríguez |
Abstract |
An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in the CSC model is that it can comprehensibly explain essential and poorly understood clinical events, such as therapy resistance, minimal residual disease, and tumor recurrence. This review discusses the recent advances in colon cancer stem cell research, the genes responsible for CSC chemoresistance, and new therapies against CSCs. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Portugal | 1 | <1% |
Iran, Islamic Republic of | 1 | <1% |
United States | 1 | <1% |
Luxembourg | 1 | <1% |
Poland | 1 | <1% |
Unknown | 134 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 29 | 21% |
Student > Master | 28 | 20% |
Researcher | 19 | 14% |
Student > Bachelor | 17 | 12% |
Student > Doctoral Student | 7 | 5% |
Other | 19 | 14% |
Unknown | 20 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 33 | 24% |
Medicine and Dentistry | 31 | 22% |
Agricultural and Biological Sciences | 30 | 22% |
Chemistry | 4 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
Other | 12 | 9% |
Unknown | 25 | 18% |