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Mdm2 Induces Mono-Ubiquitination of FOXO4

Overview of attention for article published in PLOS ONE, July 2008
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (53rd percentile)

Mentioned by

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13 patents
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5 Wikipedia pages

Citations

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113 Dimensions

Readers on

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86 Mendeley
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Title
Mdm2 Induces Mono-Ubiquitination of FOXO4
Published in
PLOS ONE, July 2008
DOI 10.1371/journal.pone.0002819
Pubmed ID
Authors

Arjan B. Brenkman, Peter L. J. de Keizer, Niels J. F. van den Broek, A. G. Jochemsen, Boudewijn M. Burgering

Abstract

The Forkhead box O (FOXO) class of transcription factors are involved in the regulation of several cellular responses including cell cycle progression and apoptosis. Furthermore, in model organisms FOXOs act as tumor suppressors and affect aging. Previously, we noted that FOXOs and p53 are remarkably similar within their spectrum of regulatory proteins. For example, the de-ubiquitinating enzyme USP7 removes ubiquitin from both FOXO and p53. However, Skp2 has been identified as E3 ligase for FOXO1, whereas Mdm2 is the prime E3 ligase for p53.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Italy 1 1%
Unknown 84 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 22 26%
Student > Ph. D. Student 17 20%
Student > Master 12 14%
Professor > Associate Professor 7 8%
Student > Bachelor 4 5%
Other 13 15%
Unknown 11 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 34 40%
Biochemistry, Genetics and Molecular Biology 28 33%
Medicine and Dentistry 6 7%
Immunology and Microbiology 2 2%
Pharmacology, Toxicology and Pharmaceutical Science 1 1%
Other 3 3%
Unknown 12 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 December 2019.
All research outputs
#4,694,486
of 22,780,967 outputs
Outputs from PLOS ONE
#64,091
of 194,391 outputs
Outputs of similar age
#15,895
of 81,816 outputs
Outputs of similar age from PLOS ONE
#189
of 461 outputs
Altmetric has tracked 22,780,967 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 194,391 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,816 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 461 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.