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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats
|
|---|---|
| Published in |
Journal of Neuroinflammation, January 2018
|
| DOI | 10.1186/s12974-018-1055-2 |
| Pubmed ID | |
| Authors |
Titikorn Chunchai, Wannipa Thunapong, Sakawdaurn Yasom, Keerati Wanchai, Sathima Eaimworawuthikul, Gabrielle Metzler, Anusorn Lungkaphin, Anchalee Pongchaidecha, Sasithorn Sirilun, Chaiyavat Chaiyasut, Wasana Pratchayasakul, Parameth Thiennimitr, Nipon Chattipakorn, Siriporn C. Chattipakorn |
| Abstract |
Chronic high-fat diet (HFD) consumption caused not only obese-insulin resistance, but also cognitive decline and microglial hyperactivity. Modified gut microbiota by prebiotics and probiotics improved obese-insulin resistance. However, the effects of prebiotics, probiotics, and synbiotics on cognition and microglial activity in an obese-insulin resistant condition have not yet been investigated. We aimed to evaluate the effect of prebiotic (Xyloolidosaccharide), probiotic (Lactobacillus paracasei HII01), or synbiotics in male obese-insulin resistant rats induced by a HFD. Male Wistar rats were fed with either a normal diet or a HFD for 12 weeks. At week 13, the rats in each dietary group were randomly divided into four subgroups including vehicle group, prebiotics group, probiotics group, and synbiotics group. Rats received their assigned intervention for an additional 12 weeks. At the end of experimental protocol, the cognitive functioning of each rat was investigated; blood and brain samples were collected to determine metabolic parameters and investigate brain pathology. We found that chronic HFD consumption leads to gut and systemic inflammation and impaired peripheral insulin sensitivity, which were improved by all treatments. Prebiotics, probiotics, or synbiotics also improved hippocampal plasticity and attenuated brain mitochondrial dysfunction in HFD-fed rats. Interestingly, hippocampal oxidative stress and apoptosis were significantly decreased in HFD-fed rats with all therapies, which also decreased microglial activation, leading to restored cognitive function. These findings suggest that consumption of prebiotics, probiotics, and synbiotics restored cognition in obese-insulin resistant subjects through gut-brain axis, leading to improved hippocampal plasticity, brain mitochondrial function, and decreased microglial activation. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 26% |
| Spain | 4 | 10% |
| Australia | 3 | 8% |
| India | 3 | 8% |
| Japan | 2 | 5% |
| Canada | 2 | 5% |
| New Zealand | 1 | 3% |
| Poland | 1 | 3% |
| France | 1 | 3% |
| Other | 4 | 10% |
| Unknown | 8 | 21% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 62% |
| Scientists | 10 | 26% |
| Science communicators (journalists, bloggers, editors) | 3 | 8% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 261 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 261 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 13% |
| Student > Bachelor | 30 | 11% |
| Student > Master | 28 | 11% |
| Researcher | 22 | 8% |
| Student > Doctoral Student | 12 | 5% |
| Other | 25 | 10% |
| Unknown | 110 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 11% |
| Medicine and Dentistry | 21 | 8% |
| Agricultural and Biological Sciences | 21 | 8% |
| Biochemistry, Genetics and Molecular Biology | 20 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 3% |
| Other | 40 | 15% |
| Unknown | 120 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 31. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 September 2022.
All research outputs
#1,303,116
of 25,670,640 outputs
Outputs from Journal of Neuroinflammation
#109
of 2,969 outputs
Outputs of similar age
#29,750
of 453,038 outputs
Outputs of similar age from Journal of Neuroinflammation
#5
of 72 outputs
Altmetric has tracked 25,670,640 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,969 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 453,038 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.