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6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression

Overview of attention for article published in Anais da Academia Brasileira de Ciências, December 2017
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Title
6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression
Published in
Anais da Academia Brasileira de Ciências, December 2017
DOI 10.1590/0001-3765201720170354
Pubmed ID
Authors

Chun Hou, Yong Miao, Hang Ji, Susheng Wang, Gang Liang, Zhihua Zhang, Weijin Hong

Abstract

6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle length, which were associated with increased expression of MMP2 and MMP9. Furthermore, the growth factors, such as EGF, KGF, VEGF, IGF-1 and TGF-β participate in the hair follicle cycle regulation and regulate hair growth. We then measured the concentrations of them using ELISA assays, and the results showed that 6-Gingerol decreased EGF, KGF, VEGF, and IGF-1 concentrations, and increased TGF-β concentration. Thus, this study showed that 6-Gingerol might act as a hair growth suppressive drug via induction of MMP2 and MMP9 expression, which could interfere with the hair cycle.

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Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Student > Postgraduate 3 19%
Student > Bachelor 2 13%
Unspecified 1 6%
Lecturer > Senior Lecturer 1 6%
Librarian 1 6%
Other 2 13%
Unknown 6 38%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 3 19%
Medicine and Dentistry 2 13%
Unspecified 1 6%
Agricultural and Biological Sciences 1 6%
Biochemistry, Genetics and Molecular Biology 1 6%
Other 2 13%
Unknown 6 38%