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Microcirculation improvement after short-term infusion of vasopressin in septic shock is dependent on noradrenaline

Overview of attention for article published in Clinics, January 2017
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Title
Microcirculation improvement after short-term infusion of vasopressin in septic shock is dependent on noradrenaline
Published in
Clinics, January 2017
DOI 10.6061/clinics/2017(12)06
Pubmed ID
Authors

Ana Paula Metran Nascente, Flávio Geraldo Rezende Freitas, Jan Bakker, Antônio Tonete Bafi, Renata Teixeira Ladeira, Luciano Cesar Pontes Azevedo, Alexandre Lima, Flavia Ribeiro Machado

Abstract

To assess the impact of vasopressin on the microcirculation and to develop a predictive model to estimate the probability of microcirculatory recruitment in patients with septic shock. This prospective interventional study included patients with septic shock receiving noradrenaline for less than 48 hours. We infused vasopressin at 0.04 U/min for one hour. Hemodynamic measurements, including sidestream dark-field imaging, were obtained immediately before vasopressin infusion, 1 hour after vasopressin infusion and 1 hour after vasopressin withdrawal. We defined patients with more than a 10% increase in total vascular density and perfused vascular density as responders. ClinicalTrials.gov: NCT02053675. Eighteen patients were included, and nine (50%) showed improved microcirculation after infusion of vasopressin. The noradrenaline dose was significantly reduced after vasopressin (p=0.001) and was higher both at baseline and during vasopressin infusion in the responders than in the non-responders. The strongest predictor for a favorable microcirculatory response was the dose of noradrenaline at baseline (OR=4.5; 95% CI: 1.2-17.0; p=0.027). For patients using a noradrenaline dose higher than 0.38 mcg/kg/min, the probability that microcirculatory perfusion would be improved with vasopressin was 53% (sensitivity 78%, specificity 77%). In patients with septic shock for no longer than 48 h, administration of vasopressin is likely to result in an improvement in microcirculation when the baseline noradrenaline dose is higher than 0.38 mcg/kg/min.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 6 21%
Student > Bachelor 5 18%
Student > Ph. D. Student 2 7%
Professor > Associate Professor 2 7%
Student > Doctoral Student 1 4%
Other 4 14%
Unknown 8 29%
Readers by discipline Count As %
Medicine and Dentistry 11 39%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Biochemistry, Genetics and Molecular Biology 1 4%
Agricultural and Biological Sciences 1 4%
Business, Management and Accounting 1 4%
Other 2 7%
Unknown 10 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2022.
All research outputs
#14,154,479
of 21,792,010 outputs
Outputs from Clinics
#525
of 1,021 outputs
Outputs of similar age
#258,095
of 445,026 outputs
Outputs of similar age from Clinics
#24
of 62 outputs
Altmetric has tracked 21,792,010 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,021 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,026 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.