Title |
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future
|
---|---|
Published in |
Cellular and Molecular Life Sciences, May 2005
|
DOI | 10.1007/s00018-005-5054-y |
Pubmed ID | |
Authors |
Y.-J. Kim, H. Uyama |
Abstract |
Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional techniques to prevent tyrosinase action encourages us to seek new potent tyrosinase inhibitors. This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance. |
Mendeley readers
Geographical breakdown
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Japan | 2 | <1% |
Nepal | 1 | <1% |
Colombia | 1 | <1% |
Chile | 1 | <1% |
Indonesia | 1 | <1% |
France | 1 | <1% |
United States | 1 | <1% |
Unknown | 588 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 137 | 23% |
Student > Master | 85 | 14% |
Student > Ph. D. Student | 72 | 12% |
Researcher | 46 | 8% |
Student > Doctoral Student | 21 | 4% |
Other | 87 | 15% |
Unknown | 150 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 102 | 17% |
Biochemistry, Genetics and Molecular Biology | 94 | 16% |
Chemistry | 91 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 45 | 8% |
Medicine and Dentistry | 33 | 6% |
Other | 58 | 10% |
Unknown | 175 | 29% |