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Decoupling circadian clock protein turnover from circadian period determination

Overview of attention for article published in Science, January 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

Citations

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69 Dimensions

Readers on

mendeley
162 Mendeley
citeulike
2 CiteULike
Title
Decoupling circadian clock protein turnover from circadian period determination
Published in
Science, January 2015
DOI 10.1126/science.1257277
Pubmed ID
Authors

L. F. Larrondo, C. Olivares-Yanez, C. L. Baker, J. J. Loros, J. C. Dunlap

Abstract

The mechanistic basis of eukaryotic circadian oscillators in model systems as diverse as Neurospora, Drosophila, and mammalian cells is thought to be a transcription-and-translation-based negative feedback loop, wherein progressive and controlled phosphorylation of one or more negative elements ultimately elicits their own proteasome-mediated degradation, thereby releasing negative feedback and determining circadian period length. The Neurospora crassa circadian negative element FREQUENCY (FRQ) exemplifies such proteins; it is progressively phosphorylated at more than 100 sites, and strains bearing alleles of frq with anomalous phosphorylation display abnormal stability of FRQ that is well correlated with altered periods or apparent arrhythmicity. Unexpectedly, we unveiled normal circadian oscillations that reflect the allelic state of frq but that persist in the absence of typical degradation of FRQ. This manifest uncoupling of negative element turnover from circadian period length determination is not consistent with the consensus eukaryotic circadian model.

Twitter Demographics

The data shown below were collected from the profiles of 50 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 4 2%
Germany 2 1%
Chile 2 1%
France 1 <1%
Netherlands 1 <1%
Portugal 1 <1%
Canada 1 <1%
Mexico 1 <1%
United States 1 <1%
Other 0 0%
Unknown 148 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 48 30%
Researcher 35 22%
Student > Bachelor 23 14%
Student > Postgraduate 12 7%
Professor 9 6%
Other 26 16%
Unknown 9 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 73 45%
Biochemistry, Genetics and Molecular Biology 36 22%
Medicine and Dentistry 10 6%
Neuroscience 5 3%
Physics and Astronomy 4 2%
Other 15 9%
Unknown 19 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 78. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2019.
All research outputs
#219,278
of 13,603,158 outputs
Outputs from Science
#7,558
of 62,623 outputs
Outputs of similar age
#5,013
of 279,930 outputs
Outputs of similar age from Science
#291
of 1,107 outputs
Altmetric has tracked 13,603,158 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 62,623 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 44.7. This one has done well, scoring higher than 87% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,930 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 1,107 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.