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Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid

Overview of attention for article published in Acta Neuropathologica Communications, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Good Attention Score compared to outputs of the same age and source (66th percentile)

Mentioned by

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6 X users
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11 patents
reddit
1 Redditor

Citations

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76 Dimensions

Readers on

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169 Mendeley
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Title
Decreased mTOR signaling pathway in human idiopathic autism and in rats exposed to valproic acid
Published in
Acta Neuropathologica Communications, January 2015
DOI 10.1186/s40478-015-0184-4
Pubmed ID
Authors

Chiara Nicolini, Younghee Ahn, Bernadeta Michalski, Jong M Rho, Margaret Fahnestock

Abstract

The molecular mechanisms underlying autistic behaviors remain to be elucidated. Mutations in genes linked to autism adversely affect molecules regulating dendritic spine formation, function and plasticity, and some increase the mammalian target of rapamycin, mTOR, a regulator of protein synthesis at spines. Here, we investigated whether the Akt/mTOR pathway is disrupted in idiopathic autism and in rats exposed to valproic acid, an animal model exhibiting autistic-like behavior.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 1%
Chile 1 <1%
Brazil 1 <1%
Hong Kong 1 <1%
Denmark 1 <1%
Canada 1 <1%
Unknown 162 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 16%
Student > Master 26 15%
Researcher 23 14%
Student > Bachelor 22 13%
Student > Doctoral Student 10 6%
Other 31 18%
Unknown 30 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 33 20%
Neuroscience 28 17%
Biochemistry, Genetics and Molecular Biology 19 11%
Medicine and Dentistry 17 10%
Psychology 17 10%
Other 13 8%
Unknown 42 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#4,832,989
of 25,874,560 outputs
Outputs from Acta Neuropathologica Communications
#877
of 1,605 outputs
Outputs of similar age
#62,205
of 361,995 outputs
Outputs of similar age from Acta Neuropathologica Communications
#6
of 18 outputs
Altmetric has tracked 25,874,560 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,605 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.8. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 361,995 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.