| Chapter title |
Cannabinoid receptors and the cytokine network.
|
|---|---|
| Chapter number | 24 |
| Book title |
Drugs of Abuse, Immunomodulation, and Aids
|
| Published in |
Advances in experimental medicine and biology, January 1998
|
| DOI | 10.1007/978-1-4615-5347-2_24 |
| Pubmed ID | |
| Book ISBNs |
978-1-4613-7439-8, 978-1-4615-5347-2
|
| Authors |
T W Klein, C Newton, H Friedman, Klein, Thomas W., Newton, Catherine, Friedman, Herman, Thomas W. Klein, Catherine Newton, Herman Friedman |
| Abstract |
Splenocyte cultures from BALB/c mice were treated with THC and mitogen and shown to produce less Th1 cytokine, IFN gamma, and more Th2 cytokines, IL-4 and IL-10. This suggested that drug treatment caused a shift in the development of Th1 and Th2 cells. In studies designed to look at molecular mechanisms, the CBI antagonist, SR141716A, did not attenuate the THC enhancement of IL-4 production, but pertussis toxin attenuated the drug effect and the CB2 agonist, JWH-051, increased IL-4 production similar to THC. These results suggest that cannabinoids may increase Th2 development and IL-4 production in cultured immune cells through the activity of the CB2 receptor subtype. Studies are currently in progress to further define the molecular and cellular mechanisms involved. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 10 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 30% |
| Student > Bachelor | 2 | 20% |
| Student > Ph. D. Student | 2 | 20% |
| Other | 1 | 10% |
| Professor > Associate Professor | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 1 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 30% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 20% |
| Biochemistry, Genetics and Molecular Biology | 1 | 10% |
| Medicine and Dentistry | 1 | 10% |
| Neuroscience | 1 | 10% |
| Other | 0 | 0% |
| Unknown | 2 | 20% |