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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Modulation of Macrophage Activation State Protects Tissue from Necrosis during Critical Limb Ischemia in Thrombospondin-1-Deficient Mice
|
|---|---|
| Published in |
PLOS ONE, December 2008
|
| DOI | 10.1371/journal.pone.0003950 |
| Pubmed ID | |
| Authors |
Nicolas Bréchot, Elisa Gomez, Marine Bignon, Jamila Khallou-Laschet, Michael Dussiot, Aurélie Cazes, Cécile Alanio-Bréchot, Mélanie Durand, Josette Philippe, Jean-Sébastien Silvestre, Nico Van Rooijen, Pierre Corvol, Antonino Nicoletti, Bénédicte Chazaud, Stéphane Germain |
| Abstract |
Macrophages, key regulators of healing/regeneration processes, strongly infiltrate ischemic tissues from patients suffering from critical limb ischemia (CLI). However pro-inflammatory markers correlate with disease progression and risk of amputation, suggesting that modulating macrophage activation state might be beneficial. We previously reported that thrombospondin-1 (TSP-1) is highly expressed in ischemic tissues during CLI in humans. TSP-1 is a matricellular protein that displays well-known angiostatic properties in cancer, and regulates inflammation in vivo and macrophages properties in vitro. We therefore sought to investigate its function in a mouse model of CLI. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 5% |
| Austria | 1 | 1% |
| Germany | 1 | 1% |
| Spain | 1 | 1% |
| Argentina | 1 | 1% |
| Unknown | 66 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 28% |
| Student > Ph. D. Student | 18 | 24% |
| Professor > Associate Professor | 8 | 11% |
| Student > Master | 7 | 9% |
| Professor | 4 | 5% |
| Other | 10 | 14% |
| Unknown | 6 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 31 | 42% |
| Medicine and Dentistry | 13 | 18% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Engineering | 4 | 5% |
| Neuroscience | 2 | 3% |
| Other | 6 | 8% |
| Unknown | 11 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 April 2022.
All research outputs
#7,194,406
of 23,466,057 outputs
Outputs from PLOS ONE
#87,826
of 200,902 outputs
Outputs of similar age
#46,294
of 170,098 outputs
Outputs of similar age from PLOS ONE
#229
of 416 outputs
Altmetric has tracked 23,466,057 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 200,902 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 170,098 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 416 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.