Title |
A Review of Epidemiologic Studies on Aluminum and Silica in Relation to Alzheimer's Disease and Associated Disorders
|
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Published in |
Reviews on Environmental Health, May 2011
|
DOI | 10.1515/reveh.2002.17.2.107 |
Pubmed ID | |
Authors |
Virginie Rondeau |
Abstract |
Although the neurotoxicity of aluminum is well established, the association between the metal and dementia or associated disorders remains a subject of debate. In this article, we present a review of articles published on epidemiologic studies of this subject. Different sources of exposure are considered (occupational exposure, aluminum-containing products), with emphasis on drinking water. We separate the various health effects of aluminum into three categories: neurological disorders (other than cognitive decline or AD); cognitive decline; and dementia or Alzheimer's disease. Furthermore, we present the results obtained on silicon in drinking water, a chemical constituent that interacts with aluminum. We conclude that not enough epidemiological evidence supports a link between aluminum in drinking water and AD. The role of silica in drinking water has been less studied, and clear results have not yet emerged. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 20% |
Italy | 1 | 10% |
Korea, Democratic People's Republic of | 1 | 10% |
United Kingdom | 1 | 10% |
Japan | 1 | 10% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 9 | 90% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Canada | 1 | 3% |
Unknown | 31 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 7 | 22% |
Student > Master | 4 | 13% |
Other | 3 | 9% |
Student > Bachelor | 3 | 9% |
Student > Ph. D. Student | 2 | 6% |
Other | 3 | 9% |
Unknown | 10 | 31% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 6 | 19% |
Medicine and Dentistry | 3 | 9% |
Agricultural and Biological Sciences | 3 | 9% |
Engineering | 2 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 5 | 16% |
Unknown | 12 | 38% |