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Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?

Overview of attention for article published in Molecular Cancer, August 2011
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

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1 X user
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1 patent
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20 Wikipedia pages

Citations

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141 Dimensions

Readers on

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205 Mendeley
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1 CiteULike
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Title
Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?
Published in
Molecular Cancer, August 2011
DOI 10.1186/1476-4598-10-101
Pubmed ID
Authors

David P Minde, Zeinab Anvarian, Stefan GD Rüdiger, Madelon M Maurice

Abstract

Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene strongly predispose to development of gastro-intestinal tumors. Central to the tumorigenic events in APC mutant cells is the uncontrolled stabilization and transcriptional activation of the protein β-catenin. Many questions remain as to how APC controls β-catenin degradation. Remarkably, the large C-terminal region of APC, which spans over 2000 amino acids and includes critical regions in downregulating β-catenin, is predicted to be natively unfolded. Here we discuss how this uncommonly large disordered region may help to coordinate the multiple cellular functions of APC. Recently, a significant number of germline and somatic missense mutations in the central region of APC were linked to tumorigenesis in the colon as well as extra-intestinal tissues. We classify and localize all currently known missense mutations in the APC structure. The molecular basis by which these mutations interfere with the function of APC remains unresolved. We propose several mechanisms by which cancer-related missense mutations in the large disordered domain of APC may interfere with tumor suppressor activity. Insight in the underlying molecular events will be invaluable in the development of novel strategies to counter dysregulated Wnt signaling by APC mutations in cancer.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 205 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 <1%
Netherlands 1 <1%
Austria 1 <1%
Canada 1 <1%
Mexico 1 <1%
Argentina 1 <1%
Unknown 199 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 47 23%
Student > Bachelor 40 20%
Researcher 29 14%
Student > Master 24 12%
Other 10 5%
Other 28 14%
Unknown 27 13%
Readers by discipline Count As %
Agricultural and Biological Sciences 63 31%
Biochemistry, Genetics and Molecular Biology 57 28%
Medicine and Dentistry 25 12%
Chemistry 8 4%
Pharmacology, Toxicology and Pharmaceutical Science 5 2%
Other 17 8%
Unknown 30 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 October 2023.
All research outputs
#4,648,295
of 24,657,405 outputs
Outputs from Molecular Cancer
#355
of 1,854 outputs
Outputs of similar age
#23,669
of 127,580 outputs
Outputs of similar age from Molecular Cancer
#5
of 18 outputs
Altmetric has tracked 24,657,405 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,854 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.5. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 127,580 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 18 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.