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Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus

Overview of attention for article published in Environmental Microbiology, March 2015
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Title
Novel host-specific iron acquisition system in the zoonotic pathogen Vibrio vulnificus
Published in
Environmental Microbiology, March 2015
DOI 10.1111/1462-2920.12782
Pubmed ID
Authors

David Pajuelo, Chung-Te Lee, Francisco J. Roig, Lien-I. Hor, Carmen Amaro

Abstract

V. vulnificus is a marine bacterium associated with human and fish (mainly farmed eels) diseases globally known as vibriosis. The ability to infect and overcome eel innate immunity relies on a virulence plasmid (pVvbt2) specific for biotype 2 (Bt2) strains. In the present study, we demonstrated that pVvbt2 encodes a host-specific iron acquisition system that depends on an outer membrane receptor for eel-transferrin called Vep20. The inactivation of vep20 did not affect either bacterial growth in human plasma or virulence for mice, while bacterial growth in eel blood/plasma was abolished and virulence for eels was significantly impaired. Furthermore, vep20 is an iron-regulated gene overexpressed in eel blood during artificially induced vibriosis both in vitro and in vivo. Interestingly, homologues to vep20 were identified in the transferable plasmids of two fish pathogen species of broad-host range, Vibrio harveyi (pVh1) and Photobacterium damselae subsp. damselae (pPHDD1). These data suggest that Vep20 belongs to a new family of plasmid-encoded fish-specific transferrin receptors, and the acquisition of these plasmids through horizontal gene transfer is likely positively selected in the fish-farming environment. Moreover, we propose Ftbp (fish transferrin binding proteins) as a formal name for this family of proteins.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 4%
Unknown 26 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 19%
Researcher 5 19%
Student > Ph. D. Student 4 15%
Student > Postgraduate 4 15%
Student > Doctoral Student 4 15%
Other 5 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 48%
Biochemistry, Genetics and Molecular Biology 4 15%
Medicine and Dentistry 2 7%
Earth and Planetary Sciences 2 7%
Immunology and Microbiology 2 7%
Other 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2016.
All research outputs
#10,943,130
of 12,348,046 outputs
Outputs from Environmental Microbiology
#2,416
of 2,625 outputs
Outputs of similar age
#217,816
of 267,604 outputs
Outputs of similar age from Environmental Microbiology
#74
of 84 outputs
Altmetric has tracked 12,348,046 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,625 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.