↓ Skip to main content

miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway

Overview of attention for article published in BMC Cell Biology, January 2017
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
23 Dimensions

Readers on

mendeley
12 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway
Published in
BMC Cell Biology, January 2017
DOI 10.1186/s12860-016-0123-7
Pubmed ID
Authors

Xiangming Zeng, Chaoqun Huang, Lakmini Senavirathna, Pengcheng Wang, Lin Liu

Abstract

MicroRNAs are a group of small RNAs that regulate gene expression at the posttranscriptional level. They regulate almost every aspect of cellular processes. In this study, we investigated whether miR-27b regulates pulmonary fibroblast activation. We found that miR-27b was down-regulated in fibrotic lungs and fibroblasts from an experimental mouse model of pulmonary fibrosis. The overexpression of miR-27b with a lentiviral vector inhibited TGFβ1-stimulated mRNA expression of collagens (COL1A1, COL3A1, and COL4A1) and alpha-smooth muscle actin, and protein expression of Col3A1 and alpha-smooth muscle actin in LL29 human pulmonary fibroblasts. miR-27b also reduced contractile activity of LL29. TGFβ receptor 1 and SMAD2 were identified as the targets of miR-27b by 3'-untranslated region luciferase reporter and western blotting assays. Our results suggest that miR-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFβ receptor 1 and SMAD2. This discovery may provide new targets for therapeutic interventions of idiopathic pulmonary fibrosis.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 12 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 25%
Student > Doctoral Student 2 17%
Student > Bachelor 1 8%
Student > Ph. D. Student 1 8%
Unknown 5 42%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 25%
Agricultural and Biological Sciences 2 17%
Psychology 1 8%
Neuroscience 1 8%
Engineering 1 8%
Other 0 0%
Unknown 4 33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 March 2020.
All research outputs
#12,194,203
of 15,341,807 outputs
Outputs from BMC Cell Biology
#219
of 297 outputs
Outputs of similar age
#263,219
of 365,081 outputs
Outputs of similar age from BMC Cell Biology
#1
of 1 outputs
Altmetric has tracked 15,341,807 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 297 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.1. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 365,081 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 15th percentile – i.e., 15% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them