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Plasmid-mediated quinolone resistance (PMQR) and mutations in the topoisomerase genes of Salmonella enterica strains from Brazil.

Overview of attention for article published in Brazilian Journal of Microbiology, October 2013
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3 tweeters

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60 Mendeley
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Title
Plasmid-mediated quinolone resistance (PMQR) and mutations in the topoisomerase genes of Salmonella enterica strains from Brazil.
Published in
Brazilian Journal of Microbiology, October 2013
DOI 10.1590/s1517-83822013000200046
Pubmed ID
Authors

Ferrari R, Galiana A, Cremades R, Rodríguez JC, Magnani M, Tognim MC, Oliveira TC, Royo G, Ferrari, Rafaela, Galiana, Antonio, Cremades, Rosa, Rodríguez, Juan Carlos, Magnani, Marciane, Tognim, M.C.B., Oliveira, Tereza C.R.M., Royo, Gloria

Abstract

The objective of this study was to identify mutations in the Quinolone Resistance Determining sources Regions (QRDR) of the gyrA, gyrB, parC, and parE genes and to determine if any of the qnr variants or the aac(6')-Ib-cr variant were present in strains of Salmonella spp. isolated in Brazil. A total of 126 Salmonella spp. strains from epidemic (n = 114) and poultry (n = 12) origin were evaluated. One hundred and twelve strains (88.8%) were resistant to nalidixic acid (NAL) and 29 (23.01%) showed a reduced susceptibility to ciprofloxacin (Cip). The mutations identified were substitutions limited to the QRDR of the gyrA gene in the codons for Serine 83, Aspartate 87 and Alanine 131. The sensitivity to NAL seems to be a good phenotypic indication of distinguishing mutated and non-mutated strains in the QRDR, however the double mutation in gyrA did not cause resistance to ciprofloxacin. The qnrA1 and qnrB19 genes were detected, respectively, in one epidemic strain of S. Enteritidis and one strain of S. Corvallis of poultry origin. Despite previous detection of qnr genes in Brazil, this is the first report of qnr gene detection in Salmonella, and also the first detection of qnrB19 gene in this country. The results alert for the continuous monitoring of quinolone resistance determinants in order to minimize the emergence and selection of Salmonella spp. strains showing reduced susceptibility or resistance to quinolones.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
Unknown 58 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 18%
Student > Master 9 15%
Student > Ph. D. Student 8 13%
Student > Doctoral Student 5 8%
Student > Bachelor 4 7%
Other 9 15%
Unknown 14 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 13 22%
Medicine and Dentistry 8 13%
Veterinary Science and Veterinary Medicine 7 12%
Biochemistry, Genetics and Molecular Biology 7 12%
Immunology and Microbiology 7 12%
Other 6 10%
Unknown 12 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 January 2015.
All research outputs
#3,725,351
of 7,628,949 outputs
Outputs from Brazilian Journal of Microbiology
#53
of 160 outputs
Outputs of similar age
#108,417
of 237,076 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#1
of 2 outputs
Altmetric has tracked 7,628,949 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 160 research outputs from this source. They receive a mean Attention Score of 1.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 237,076 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 2 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them