Title |
Perilesional edema in radiation necrosis reflects axonal degeneration
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Published in |
Radiation Oncology, January 2015
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DOI | 10.1186/s13014-015-0335-6 |
Pubmed ID | |
Authors |
Carlos J Perez-Torres, Liya Yuan, Robert E Schmidt, Keith M Rich, Joseph JH Ackerman, Joel R Garbow |
Abstract |
BackgroundRecently, we characterized a Gamma Knife® radiation necrosis mouse model with various magnetic resonance imaging (MRI) protocols to identify biomarkers useful in differentiation from tumors. Though the irradiation was focal to one hemisphere, a contralateral injury was observed that appeared to be localized in the white matter only. Interestingly, this injury was identifiable in T2-weighted images, apparent diffusion coefficient (ADC), and magnetization transfer ratio (MTR) maps, but not on post-contrast T1-weighted images. This observation of edema independent of vascular changes is akin to the perilesional edema seen in clinical radiation necrosis.FindingsThe pathology underlying the observed white-matter MRI changes was explored by performing immunohistochemistry for healthy axons and myelin. The presence of both healthy axons and myelin was reduced in the contralateral white-matter lesion.ConclusionsBased on our immunohistochemical findings, the contralateral white-matter injury is most likely due to axonal degeneration. |
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