| Chapter title |
Exosomes for immunotherapy of cancer.
|
|---|---|
| Chapter number | 17 |
| Book title |
New Trends in Cancer for the 21 st Century
|
| Published in |
Advances in experimental medicine and biology, January 2003
|
| DOI | 10.1007/978-1-4615-0081-0_17 |
| Pubmed ID | |
| Book ISBNs |
978-1-4613-4914-3, 978-1-4615-0081-0
|
| Authors |
Chaput, Nathalie, Schartz, N E C, Andre, Fabrice, Zitvogel, Laurence, Schartz, N. E. C. |
| Abstract |
Exosomes are 60 to 90 nm membrane vesicles originating from late endosomes and secreted from most hematopoietic and epithelial cells in vitro. B cell derived-exosome antigenicity was first reported in 1996 in MHC class II restricted CD4+ T lymphocytes. In 1998, we reported that dendritic cell derived-exosomes are immunogenic in mice leading to tumor rejection. These findings have renewed the interest in exosomes. The current challenge consists in understanding the mechanisms and the physiological relevance of exosomes that could contribute to the design of the optimal exosome based-vaccination. Here, we will focus on the biological features pertaining to dendritic cell- and tumor cell derived-exosomes and will discuss their potential clinical implementation. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Unknown | 33 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 18% |
| Student > Ph. D. Student | 5 | 15% |
| Student > Master | 4 | 12% |
| Professor > Associate Professor | 3 | 9% |
| Professor | 3 | 9% |
| Other | 4 | 12% |
| Unknown | 9 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 26% |
| Medicine and Dentistry | 6 | 18% |
| Immunology and Microbiology | 4 | 12% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Neuroscience | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 9 | 26% |