Title |
Functional subsensitivity of 5-HT2A and 5-HT2C receptors mediating hyperthermia following acute and chronic treatment with 5-HT2A/2C receptor antagonists
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Published in |
Psychopharmacology, March 1997
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DOI | 10.1007/s002130050222 |
Pubmed ID | |
Authors |
P. Mazzola-Pomietto, Charanjit S. Aulakh, Teresa Tolliver, Dennis L. Murphy |
Abstract |
In the present study, we investigated the duration of attenuation of the temperature increases produced by (+/-) 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and m-chlorophenylpiperazine (m-CPP) which followed pretreatment with four serotonin (5-HT) antagonists; metergoline, mesulergine, mianserin and ritanserin. The duration of attenuation of m-CPP-induced hyperthermia lasted less than 1 day for ritanserin, more than 1 day for the 5 mg/kg doses of both mianserin and metergoline and more than 2 days for the 5 mg/kg dose of mesulergine. The duration of attenuation of DOI-induced hyperthermia lasted less than 1 day for ritanserin, more than 1 day for mianserin, more than 2 days for the 5 mg/kg dose of metergoline and more than 4 days for mesulergine. Daily administration of a low (1.0 mg/kg per day) dose of ritanserin for 14 days led to an attenuation of the temperature increases produced by m-CPP given 24 h after the last dose of ritanserin, but did not cause a similar desensitization of DOI-induced hyperthermia. On the other hand, daily administration of both low (1.0 mg/kg per day) and high (5.0 mg/kg per day) doses of mianserin for 14 days caused desensitization of DOI-induced hyperthermia but did not cause desensitization of m-CPP-induced hyperthermia when these agonists were administered 48 h after the last dose of mianserin. These findings demonstrate functional subsensitivity of both 5-HT2A and 5-HT2C receptors mediating hyperthermia following both acute and chronic administration of 5-HT2A/5-HT2C receptor antagonists; some differences in time course and in responses to individual antagonists at 5-HT2A versus 5-HT2C sites were also observed. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 6% |
Unknown | 16 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 35% |
Researcher | 4 | 24% |
Student > Ph. D. Student | 2 | 12% |
Professor | 1 | 6% |
Unspecified | 1 | 6% |
Other | 2 | 12% |
Unknown | 1 | 6% |
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Pharmacology, Toxicology and Pharmaceutical Science | 2 | 12% |
Chemistry | 2 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Unspecified | 1 | 6% |
Other | 0 | 0% |
Unknown | 2 | 12% |