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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
|
|---|---|
| Published in |
Nature Genetics, January 2018
|
| DOI | 10.1038/s41588-018-0044-9 |
| Pubmed ID | |
| Authors |
Rhamy Zeid, Matthew A. Lawlor, Evon Poon, Jaime M. Reyes, Mariateresa Fulciniti, Michael A. Lopez, Thomas G. Scott, Behnam Nabet, Michael A. Erb, Georg E. Winter, Zoe Jacobson, Donald R. Polaski, Kristen L. Karlin, Rachel A. Hirsch, Nikhil P. Munshi, Thomas F. Westbrook, Louis Chesler, Charles Y. Lin, James E. Bradner |
| Abstract |
Amplification of the locus encoding the oncogenic transcription factor MYCN is a defining feature of high-risk neuroblastoma. Here we present the first dynamic chromatin and transcriptional landscape of MYCN perturbation in neuroblastoma. At oncogenic levels, MYCN associates with E-box binding motifs in an affinity-dependent manner, binding to strong canonical E-boxes at promoters and invading abundant weaker non-canonical E-boxes clustered at enhancers. Loss of MYCN leads to a global reduction in transcription, which is most pronounced at MYCN target genes with the greatest enhancer occupancy. These highly occupied MYCN target genes show tissue-specific expression and are linked to poor patient survival. The activity of genes with MYCN-occupied enhancers is dependent on the tissue-specific transcription factor TWIST1, which co-occupies enhancers with MYCN and is required for MYCN-dependent proliferation. These data implicate tissue-specific enhancers in defining often highly tumor-specific 'MYC target gene signatures' and identify disruption of the MYCN enhancer regulatory axis as a promising therapeutic strategy in neuroblastoma. |
X Demographics
The data shown below were collected from the profiles of 40 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 48% |
| Germany | 4 | 10% |
| United Kingdom | 2 | 5% |
| Switzerland | 1 | 3% |
| Lebanon | 1 | 3% |
| Qatar | 1 | 3% |
| France | 1 | 3% |
| Spain | 1 | 3% |
| Canada | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 8 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 22 | 55% |
| Scientists | 15 | 38% |
| Practitioners (doctors, other healthcare professionals) | 2 | 5% |
| Science communicators (journalists, bloggers, editors) | 1 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 194 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 22% |
| Researcher | 37 | 19% |
| Student > Master | 21 | 11% |
| Student > Bachelor | 17 | 9% |
| Student > Doctoral Student | 6 | 3% |
| Other | 24 | 12% |
| Unknown | 46 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 78 | 40% |
| Agricultural and Biological Sciences | 32 | 16% |
| Medicine and Dentistry | 16 | 8% |
| Computer Science | 3 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 2% |
| Other | 14 | 7% |
| Unknown | 48 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2018.
All research outputs
#1,659,804
of 24,633,436 outputs
Outputs from Nature Genetics
#2,353
of 7,449 outputs
Outputs of similar age
#39,231
of 451,377 outputs
Outputs of similar age from Nature Genetics
#50
of 67 outputs
Altmetric has tracked 24,633,436 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,449 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 42.6. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,377 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 67 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.