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Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury

Overview of attention for article published in Journal of Neuroinflammation, June 2008
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Title
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury
Published in
Journal of Neuroinflammation, June 2008
DOI 10.1186/1742-2094-5-26
Pubmed ID
Authors

Hal X Nguyen, Manuel D Galvan, Aileen J Anderson

Abstract

The complement system has been suggested to affect injury or disease of the central nervous system (CNS) by regulating numerous physiological events and pathways. The activation of complement following traumatic CNS injury can also result in the formation and deposition of C5b-9 membrane attack complex (C5b-9/MAC), causing cell lysis or sublytic effects on vital CNS cells. Although complement proteins derived from serum/blood-brain barrier breakdown can contribute to injury or disease, infiltrating immune cells may represent an important local source of complement after injury. As the first immune cells to infiltrate the CNS within hours post-injury, polymorphonuclear leukocytes (PMNs) may affect injury through mechanisms associated with complement-mediated events. However, the expression/association of both early and terminal complement proteins by PMNs has not been fully characterized in vitro, and has not observed previously in vivo after traumatic spinal cord injury (SCI).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Chile 1 2%
United States 1 2%
Unknown 49 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 19%
Student > Ph. D. Student 7 13%
Student > Doctoral Student 5 10%
Student > Bachelor 5 10%
Student > Master 4 8%
Other 7 13%
Unknown 14 27%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 19%
Neuroscience 7 13%
Biochemistry, Genetics and Molecular Biology 6 12%
Medicine and Dentistry 5 10%
Psychology 3 6%
Other 8 15%
Unknown 13 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 December 2022.
All research outputs
#7,633,928
of 23,257,423 outputs
Outputs from Journal of Neuroinflammation
#1,243
of 2,684 outputs
Outputs of similar age
#28,972
of 83,038 outputs
Outputs of similar age from Journal of Neuroinflammation
#3
of 7 outputs
Altmetric has tracked 23,257,423 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,684 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 83,038 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.