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Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury

Overview of attention for article published in Journal of Neuroinflammation, June 2008
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

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1 Wikipedia page

Citations

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36 Dimensions

Readers on

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32 Mendeley
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Title
Characterization of early and terminal complement proteins associated with polymorphonuclear leukocytes in vitro and in vivo after spinal cord injury
Published in
Journal of Neuroinflammation, June 2008
DOI 10.1186/1742-2094-5-26
Pubmed ID
Authors

Hal X Nguyen, Manuel D Galvan, Aileen J Anderson

Abstract

The complement system has been suggested to affect injury or disease of the central nervous system (CNS) by regulating numerous physiological events and pathways. The activation of complement following traumatic CNS injury can also result in the formation and deposition of C5b-9 membrane attack complex (C5b-9/MAC), causing cell lysis or sublytic effects on vital CNS cells. Although complement proteins derived from serum/blood-brain barrier breakdown can contribute to injury or disease, infiltrating immune cells may represent an important local source of complement after injury. As the first immune cells to infiltrate the CNS within hours post-injury, polymorphonuclear leukocytes (PMNs) may affect injury through mechanisms associated with complement-mediated events. However, the expression/association of both early and terminal complement proteins by PMNs has not been fully characterized in vitro, and has not observed previously in vivo after traumatic spinal cord injury (SCI).

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Chile 1 3%
United Kingdom 1 3%
United States 1 3%
Unknown 29 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 25%
Student > Ph. D. Student 6 19%
Student > Doctoral Student 5 16%
Student > Bachelor 4 13%
Student > Postgraduate 4 13%
Other 5 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 31%
Medicine and Dentistry 5 16%
Biochemistry, Genetics and Molecular Biology 4 13%
Immunology and Microbiology 3 9%
Neuroscience 3 9%
Other 7 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2012.
All research outputs
#816,480
of 3,629,479 outputs
Outputs from Journal of Neuroinflammation
#110
of 533 outputs
Outputs of similar age
#24,435
of 94,291 outputs
Outputs of similar age from Journal of Neuroinflammation
#1
of 23 outputs
Altmetric has tracked 3,629,479 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 533 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 76% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,291 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.