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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Structural and mechanistic divergence of the small (p)ppGpp synthetases RelP and RelQ
|
|---|---|
| Published in |
Scientific Reports, February 2018
|
| DOI | 10.1038/s41598-018-20634-4 |
| Pubmed ID | |
| Authors |
Wieland Steinchen, Marian S. Vogt, Florian Altegoer, Pietro I. Giammarinaro, Petra Horvatek, Christiane Wolz, Gert Bange |
| Abstract |
The nutritional alarmones ppGpp and pppGpp (collectively: (p)ppGpp) are nucleotide-based second messengers enabling bacteria to respond to environmental and stress conditions. Several bacterial species contain two highly homologous (p)ppGpp synthetases named RelP (SAS2, YwaC) and RelQ (SAS1, YjbM). It is established that RelQ forms homotetramers that are subject to positive allosteric regulation by pppGpp, but structural and mechanistic insights into RelP lack behind. Here we present a structural and mechanistic characterization of RelP. In stark contrast to RelQ, RelP is not allosterically regulated by pppGpp and displays a different enzyme kinetic behavior. This discrepancy is evoked by different conformational properties of the guanosine-substrate binding site (G-Loop) of both proteins. Our study shows how minor structural divergences between close homologues result in new functional features during the course of molecular evolution. |
X Demographics
The data shown below were collected from the profiles of 10 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 30% |
| Sweden | 2 | 20% |
| United Kingdom | 1 | 10% |
| United States | 1 | 10% |
| Australia | 1 | 10% |
| Unknown | 2 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 5 | 50% |
| Members of the public | 5 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 71 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 16 | 23% |
| Student > Bachelor | 8 | 11% |
| Student > Ph. D. Student | 7 | 10% |
| Researcher | 5 | 7% |
| Student > Doctoral Student | 3 | 4% |
| Other | 10 | 14% |
| Unknown | 22 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 27% |
| Agricultural and Biological Sciences | 15 | 21% |
| Chemistry | 7 | 10% |
| Immunology and Microbiology | 4 | 6% |
| Engineering | 2 | 3% |
| Other | 3 | 4% |
| Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 February 2018.
All research outputs
#6,789,456
of 24,990,015 outputs
Outputs from Scientific Reports
#45,871
of 137,070 outputs
Outputs of similar age
#128,810
of 451,104 outputs
Outputs of similar age from Scientific Reports
#1,368
of 3,903 outputs
Altmetric has tracked 24,990,015 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 137,070 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 451,104 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 3,903 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.