Title |
NACP/α-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy
|
---|---|
Published in |
Acta Neuropathologica, October 1998
|
DOI | 10.1007/s004010050917 |
Pubmed ID | |
Authors |
K. Arima, Kenji Uéda, Nobuhiko Sunohara, Kenji Arakawa, Shigeo Hirai, Minako Nakamura, Haruko Tonozuka-Uehara, Mitsuru Kawai |
Abstract |
We examined neuronal cytoplasmic inclusions (NCIs) and oligodendrocytic glial cytoplasmic inclusions (GCIs) in the pontine nuclei in multiple system atrophy (MSA) using antibodies against the non-amyloid beta component of Alzheimer's disease amyloid precursor protein (NACP/alpha-synuclein). Our immunohistochemical study revealed that anti-NACP antibodies labeled both NCIs and GCIs. Immunoelectron microscopy showed that positive reaction products were localized on the 15- to 30-nm-thick filamentous components of NCIs and GCIs. The present study demonstrates that NACP is associated with cytoplasmic inclusions of MSA, and suggests a role of NACP in abnormal filament aggregation in neuronal degeneration. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Costa Rica | 1 | 1% |
Panama | 1 | 1% |
Unknown | 71 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 20 | 27% |
Researcher | 11 | 15% |
Student > Master | 7 | 10% |
Professor | 6 | 8% |
Student > Doctoral Student | 5 | 7% |
Other | 14 | 19% |
Unknown | 10 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 16 | 22% |
Medicine and Dentistry | 15 | 21% |
Neuroscience | 13 | 18% |
Biochemistry, Genetics and Molecular Biology | 10 | 14% |
Chemistry | 3 | 4% |
Other | 2 | 3% |
Unknown | 14 | 19% |