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The Growth Suppressing Effects of Girinimbine on Hepg2 Involve Induction of Apoptosis and Cell Cycle Arrest

Overview of attention for article published in Molecules, August 2011
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

wikipedia
2 Wikipedia pages

Citations

dimensions_citation
39 Dimensions

Readers on

mendeley
63 Mendeley
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Title
The Growth Suppressing Effects of Girinimbine on Hepg2 Involve Induction of Apoptosis and Cell Cycle Arrest
Published in
Molecules, August 2011
DOI 10.3390/molecules16087155
Pubmed ID
Authors

Suvitha Syam, Ahmad Bustamam Abdul, Mohd. Aspollah Sukari, Syam Mohan, Siddig Ibrahim Abdelwahab, Tang Sook Wah

Abstract

Murraya koenigii is an edible herb widely used in folk medicine. Here we report that girinimbine, a carbazole alkaloid isolated from this plant, inhibited the growth and induced apoptosis in human hepatocellular carcinoma, HepG2 cells. The MTT and LDH assay results showed that girinimbine decreased cell viability and increased cytotoxicity in a dose-and time-dependent manner selectively. Girinimbine-treated HepG2 cells showed typical morphological features of apoptosis, as observed from normal inverted microscopy and Hoechst 33342 assay. Furthermore, girinimbine treatment resulted in DNA fragmentation and elevated levels of caspase-3 in HepG2 cells. Girinimbine treatment also displayed a time-dependent accumulation of the Sub-G(0)/G(1) peak (hypodiploid) and caused G(0)/G(1)-phase arrest. Together, these results demonstrated for the first time that girinimbine could effectively induce programmed cell death in HepG2 cells and suggests the importance of conducting further investigations in preclinical human hepatocellular carcinoma models, especially on in vivo efficacy, to promote girinimbine for use as an anticancer agent against hepatocellular carcinoma.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 2%
India 1 2%
Puerto Rico 1 2%
China 1 2%
Unknown 59 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 18 29%
Student > Master 11 17%
Student > Bachelor 7 11%
Researcher 6 10%
Student > Postgraduate 5 8%
Other 11 17%
Unknown 5 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 26 41%
Medicine and Dentistry 9 14%
Pharmacology, Toxicology and Pharmaceutical Science 8 13%
Chemistry 8 13%
Nursing and Health Professions 1 2%
Other 3 5%
Unknown 8 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2016.
All research outputs
#3,500,655
of 12,226,671 outputs
Outputs from Molecules
#828
of 6,494 outputs
Outputs of similar age
#80,361
of 270,651 outputs
Outputs of similar age from Molecules
#20
of 91 outputs
Altmetric has tracked 12,226,671 research outputs across all sources so far. This one is in the 49th percentile – i.e., 49% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,494 research outputs from this source. They receive a mean Attention Score of 2.4. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 270,651 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.