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Mendeley readers
Attention Score in Context
| Title |
Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration
|
|---|---|
| Published in |
PLOS ONE, May 2008
|
| DOI | 10.1371/journal.pone.0002091 |
| Pubmed ID | |
| Authors |
Jeffrey A. Canter, Lana M. Olson, Kylee Spencer, Nathalie Schnetz-Boutaud, Brent Anderson, Michael A. Hauser, Silke Schmidt, Eric A. Postel, Anita Agarwal, Margaret A. Pericak-Vance, Paul Sternberg, Jonathan L. Haines |
| Abstract |
The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for age-related macular degeneration (AMD). A preliminary study of 393 individuals (293 cases and 100 controls) ascertained at Vanderbilt revealed an increased occurrence of 4917G in cases compared to controls (15.4% vs.9.0%, p = 0.11). Since there was a significant age difference between cases and controls in this initial analysis, we extended the study by selecting Caucasian pairs matched at the exact age at examination. From the 1547 individuals in the Vanderbilt/Duke AMD population association study (including 157 in the preliminary study), we were able to match 560 (280 cases and 280 unaffected) on exact age at examination. This study population was genotyped for 4917G plus specific AMD-associated nuclear genome polymorphisms in CFH, LOC387715 and ApoE. Following adjustment for the listed nuclear genome polymorphisms, 4917G independently predicts the presence of AMD (OR = 2.16, 95%CI 1.20-3.91, p = 0.01). In conclusion, a specific mitochondrial polymorphism previously implicated in other neurodegenerative phenotypes (4917G) appears to convey risk for AMD independent of recently discovered nuclear DNA polymorphisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Austria | 1 | 2% |
| Unknown | 46 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 20% |
| Researcher | 10 | 20% |
| Student > Doctoral Student | 6 | 12% |
| Student > Bachelor | 5 | 10% |
| Other | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 6 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 33% |
| Medicine and Dentistry | 14 | 29% |
| Biochemistry, Genetics and Molecular Biology | 7 | 14% |
| Neuroscience | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Other | 3 | 6% |
| Unknown | 6 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2023.
All research outputs
#4,695,422
of 22,785,242 outputs
Outputs from PLOS ONE
#64,093
of 194,455 outputs
Outputs of similar age
#15,243
of 78,809 outputs
Outputs of similar age from PLOS ONE
#141
of 335 outputs
Altmetric has tracked 22,785,242 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 194,455 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 78,809 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 335 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.