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Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women

Overview of attention for article published in Cochrane database of systematic reviews, March 2010
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Title
Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women
Published in
Cochrane database of systematic reviews, March 2010
DOI 10.1002/14651858.cd008440
Pubmed ID
Authors

Amy S Sturt, Emily Kainne Dokubo, Tin Tin Sint

Abstract

This systematic review focuses on antiretroviral therapy (ART) for treating human immunodeficiency virus (HIV) infection in ART-eligible pregnant women. Mother-to-child transmission (MTCT) is the primary means by which children worldwide acquire HIV infection. MTCT occurs during three major timepoints during pregnancy and the postpartum period: in utero, intrapartum, and during breastfeeding. Strategies to reduce MTCT focus on these periods of exposure and include maternal and infant use of ART, caesarean section before onset of labour or rupture of membranes, and complete avoidance of breastfeeding. Where these combined interventions are available, the risk of MTCT is as low as 1-2%. Thus, ART used among mothers who require treatment of HIV for their own health also plays a significant role in decreasing MTCT.This review is one in a series of systematic reviews performed in preparation for the revision of the 2006 World Health Organization (WHO) Guidelines regarding "Antiretroviral Drugs for Treating Pregnant Women and Preventing HIV Infection in Infants" and "Antiretroviral therapy (ART) for HIV Infections in Adults and Adolescents." The findings from these reviews were discussed with experts, key stakeholders, and country representatives at the 2009 WHO guideline review meeting. The resulting WHO 2009 "rapid advice" preliminary guidance on adult and adolescent ART now recommends lifelong treatment for all adults with HIV infection and CD4 counts <350 cells/mm(3). These recommendations also apply to pregnant women who are HIV-infected and they place a high value on early ART to benefit the mother's own health (WHO 2009). The "rapid advice" preliminary guidance also aims to minimize side effects for mothers and their infants (WHO 2009).

Mendeley readers

The data shown below were compiled from readership statistics for 247 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 <1%
Unknown 246 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 4%
Student > Postgraduate 7 3%
Student > Bachelor 5 2%
Researcher 4 2%
Unspecified 3 1%
Other 8 3%
Unknown 210 85%
Readers by discipline Count As %
Medicine and Dentistry 23 9%
Unspecified 4 2%
Nursing and Health Professions 3 1%
Immunology and Microbiology 2 <1%
Agricultural and Biological Sciences 2 <1%
Other 3 1%
Unknown 210 85%