Title |
Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities
|
---|---|
Published in |
Gut Pathogens, January 2018
|
DOI | 10.1186/s13099-018-0230-4 |
Pubmed ID | |
Authors |
Dachao Liang, Ross Ka-Kit Leung, Wenda Guan, William W. Au |
Abstract |
The commensal, symbiotic, and pathogenic microbial community which resides inside our body and on our skin (the human microbiome) can perturb host energy metabolism and immunity, and thus significantly influence development of a variety of human diseases. Therefore, the field has attracted unprecedented attention in the last decade. Although a large amount of data has been generated, there are still many unanswered questions and no universal agreements on how microbiome affects human health have been agreed upon. Consequently, this review was written to provide an updated overview of the rapidly expanding field, with a focus on revealing knowledge gaps and research opportunities. Specifically, the review covered animal physiology, optimal microbiome standard, health intervention by manipulating microbiome, knowledge base building by text mining, microbiota community structure and its implications in human diseases and health monitoring by analyzing microbiome in the blood. The review should enhance interest in conducting novel microbiota investigations that will further improve health and therapy. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 26% |
Spain | 2 | 9% |
United Kingdom | 2 | 9% |
India | 1 | 4% |
United Arab Emirates | 1 | 4% |
Unknown | 11 | 48% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 12 | 52% |
Scientists | 7 | 30% |
Science communicators (journalists, bloggers, editors) | 2 | 9% |
Practitioners (doctors, other healthcare professionals) | 2 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 422 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 66 | 16% |
Student > Bachelor | 55 | 13% |
Student > Master | 52 | 12% |
Researcher | 42 | 10% |
Student > Postgraduate | 21 | 5% |
Other | 68 | 16% |
Unknown | 118 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 86 | 20% |
Agricultural and Biological Sciences | 62 | 15% |
Immunology and Microbiology | 33 | 8% |
Medicine and Dentistry | 28 | 7% |
Nursing and Health Professions | 17 | 4% |
Other | 58 | 14% |
Unknown | 138 | 33% |