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Synthesis of novel quinine analogs and evaluation of their effects on Trypanosoma cruzi

Overview of attention for article published in Future Medicinal Chemistry, February 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Good Attention Score compared to outputs of the same age and source (72nd percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
5 Dimensions

Readers on

mendeley
13 Mendeley
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Title
Synthesis of novel quinine analogs and evaluation of their effects on Trypanosoma cruzi
Published in
Future Medicinal Chemistry, February 2018
DOI 10.4155/fmc-2017-0184
Pubmed ID
Authors

Ligia F Ceole, Hirenkumar Gandhi, Luz H Villamizar, Maurilio J Soares, Timothy P O'Sullivan

Abstract

Chagas disease is a tropical disease caused by the hemoflagellate protozoan Trypanosoma cruzi. There is no vaccine for Chagas disease and available drugs (e.g., benznidazole) are effective only during the acute phase, displaying a variable curative activity in the established chronic form of the disease. New leads with high efficacy and better toxicity profiles are urgently required. Materials & methods: A library of novel quinine derivatives was synthesized using Heck chemistry and evaluated against the various developmental forms of T. cruzi. Several novel quinine analogs with trypanocidal activity have been identified with the para-nitro-substituted derivative displaying a submicromolar IC50, which is 83-times lower than quinine and three-times lower than benznidazole. Transmission electron microscopy analysis demonstrated that these compounds induced a marked vacuolization of the kinetoplast of intracellular amastigotes and cell-derived trypomastigotes.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 13 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 38%
Other 1 8%
Unknown 7 54%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 3 23%
Agricultural and Biological Sciences 1 8%
Chemistry 1 8%
Design 1 8%
Unknown 7 54%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2019.
All research outputs
#4,830,568
of 15,426,370 outputs
Outputs from Future Medicinal Chemistry
#214
of 873 outputs
Outputs of similar age
#131,364
of 366,663 outputs
Outputs of similar age from Future Medicinal Chemistry
#7
of 25 outputs
Altmetric has tracked 15,426,370 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 873 research outputs from this source. They receive a mean Attention Score of 4.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 366,663 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.