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Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans

Overview of attention for article published in Fungal Biology and Biotechnology, February 2018
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  • Above-average Attention Score compared to outputs of the same age (60th percentile)

Mentioned by

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4 tweeters
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2 Facebook pages

Citations

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4 Dimensions

Readers on

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30 Mendeley
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Title
Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans
Published in
Fungal Biology and Biotechnology, February 2018
DOI 10.1186/s40694-018-0046-5
Pubmed ID
Authors

Zinnat Shahina, Amira M. El-Ganiny, Jessica Minion, Malcolm Whiteway, Taranum Sultana, Tanya E. S. Dahms

Abstract

Cinnamon (Cinnamomum zeylanicum)bark extract exhibits potent inhibitory activity againstCandida albicansbut the antifungal mechanisms of this essential oil remain largely unexplored. We analyzed the impact of cinnamon bark oil onC. albicansRSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62.5 μg/mL). Atomic force microscopy revealed cell surface exfoliation, altered ultrastructure and reduced cell wall integrity for both RSY150 and clinical isolates exposed to cinnamon bark oil. Cell wall damage induced by cinnamon bark oil was confirmed by exposure to stressors and the sensitivity of cell wall mutants involved in cell wall organization, biogenesis, and morphogenesis. The essential oil triggered cell cycle arrest by disrupting beta tubulin distribution, which led to mitotic spindle defects, ultimately compromising the cell membrane and allowing leakage of cellular components. The multiple targets of cinnamon bark oil can be attributed to its components, including cinnamaldehyde (74%), and minor components (< 6%) such as linalool (3.9%), cinamyl acetate (3.8%), α-caryophyllene (5.3%) and limonene (2%). Complete inhibition of the mitotic spindle assembly was observed inC. albicanstreated with cinnamaldehyde at MIC (112 μg/mL). Since cinnamaldehyde disrupts both the cell wall and tubulin polymerization, it may serve as an effective antifungal, either by chemical modification to improve its specificity and efficacy or in combination with other antifungal drugs.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 23%
Student > Ph. D. Student 5 17%
Student > Bachelor 5 17%
Student > Postgraduate 4 13%
Student > Doctoral Student 2 7%
Other 2 7%
Unknown 5 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 7 23%
Agricultural and Biological Sciences 5 17%
Medicine and Dentistry 3 10%
Pharmacology, Toxicology and Pharmaceutical Science 2 7%
Immunology and Microbiology 2 7%
Other 5 17%
Unknown 6 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2018.
All research outputs
#7,078,410
of 13,791,430 outputs
Outputs from Fungal Biology and Biotechnology
#36
of 76 outputs
Outputs of similar age
#138,575
of 354,737 outputs
Outputs of similar age from Fungal Biology and Biotechnology
#1
of 1 outputs
Altmetric has tracked 13,791,430 research outputs across all sources so far. This one is in the 48th percentile – i.e., 48% of other outputs scored the same or lower than it.
So far Altmetric has tracked 76 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 354,737 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them