↓ Skip to main content

Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration

Overview of attention for article published in Cell & Bioscience, March 2011
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (87th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

blogs
1 blog
twitter
1 X user
wikipedia
3 Wikipedia pages

Citations

dimensions_citation
105 Dimensions

Readers on

mendeley
117 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Chloroquine treatment of ARPE-19 cells leads to lysosome dilation and intracellular lipid accumulation: possible implications of lysosomal dysfunction in macular degeneration
Published in
Cell & Bioscience, March 2011
DOI 10.1186/2045-3701-1-10
Pubmed ID
Authors

Patrick M Chen, Zoë J Gombart, Jeff W Chen

Abstract

Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people over 60. The pathogenesis is still unclear. It has been suggested that lysosomal stress may lead to drusen formation, a biomarker of AMD. In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 117 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Spain 1 <1%
United Kingdom 1 <1%
Unknown 113 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 21%
Researcher 22 19%
Student > Bachelor 14 12%
Student > Doctoral Student 10 9%
Student > Master 9 8%
Other 12 10%
Unknown 25 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 36 31%
Biochemistry, Genetics and Molecular Biology 21 18%
Medicine and Dentistry 14 12%
Pharmacology, Toxicology and Pharmaceutical Science 6 5%
Immunology and Microbiology 4 3%
Other 11 9%
Unknown 25 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 December 2020.
All research outputs
#3,331,283
of 25,373,627 outputs
Outputs from Cell & Bioscience
#90
of 1,178 outputs
Outputs of similar age
#14,798
of 119,676 outputs
Outputs of similar age from Cell & Bioscience
#1
of 5 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,178 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 119,676 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them