Title |
Current therapies in alleviating liver disorders and cancers with a special focus on the potential of vitamin D
|
---|---|
Published in |
Nutrition & Metabolism, February 2018
|
DOI | 10.1186/s12986-018-0251-5 |
Pubmed ID | |
Authors |
Shahida Khan, Ashraf Ali, Sarah Khan, Ahmed Bakillah, Ghazi Damanhouri, Aziz Khan, Ahmed Makki, Ibtehal AlAnsari, Naheed Banu |
Abstract |
Liver dysfunction is a topic of global concern with many advancing therapies being researched. Though vitamin D takes a center place, other therapies especially nutritional are also gaining ground. Vitamin D has gone beyond its role in skeletal disorders by showcasing its associations in other metabolic dysfunctions too. Epidemiological evidences show a correlation between the status of vitamin D and different forms of cancer. Vitamin D receptors and alterations in gene expression appear decisive in the development of chronic liver disorders. Nutritional status therefore plays a significant role in avoiding the complications related to liver dysfunctions, making it mandatory in maintaining vitamin D sufficiency in the body. Therapies with omega-3 fatty acids, antioxidants, amino acids, steroids also render benefits which could be further explored. Recent research on the progression of certain forms of liver cancer using vitamin D analogs like Seocalcitol EB 1089 has shown good promise. The anti-inflammatory and immuno- regulatory properties of vitamin D makes its analogs, suitable candidates of better choice for the prevention and treatment of liver disorders and cancer. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Portugal | 1 | 20% |
Switzerland | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 4 | 80% |
Science communicators (journalists, bloggers, editors) | 1 | 20% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 81 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 17 | 21% |
Researcher | 7 | 9% |
Student > Master | 7 | 9% |
Other | 6 | 7% |
Student > Ph. D. Student | 5 | 6% |
Other | 10 | 12% |
Unknown | 29 | 36% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 21 | 26% |
Nursing and Health Professions | 10 | 12% |
Biochemistry, Genetics and Molecular Biology | 5 | 6% |
Agricultural and Biological Sciences | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
Other | 8 | 10% |
Unknown | 31 | 38% |