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Mendeley readers
Title |
The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer
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Published in |
Journal of neural transmission, June 1992
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DOI | 10.1007/bf01244820 |
Pubmed ID | |
Authors |
J. Hyttel, K. P. Bøgesø, J. Perregaard, C. Sánchez |
Abstract |
The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers*) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates. |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 1% |
Denmark | 1 | 1% |
Argentina | 1 | 1% |
Unknown | 69 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 13 | 18% |
Student > Bachelor | 12 | 17% |
Student > Master | 10 | 14% |
Researcher | 8 | 11% |
Professor | 4 | 6% |
Other | 9 | 13% |
Unknown | 16 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 19 | 26% |
Medicine and Dentistry | 9 | 13% |
Agricultural and Biological Sciences | 9 | 13% |
Neuroscience | 6 | 8% |
Psychology | 3 | 4% |
Other | 10 | 14% |
Unknown | 16 | 22% |