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Cannabinoid Pharmacology, Volume 80

Overview of attention for book
Attention for Chapter: Cannabinoids and Pain: Sites and Mechanisms of Action
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (53rd percentile)

Mentioned by

4 tweeters


1 Dimensions

Readers on

227 Mendeley
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Chapter title
Cannabinoids and Pain: Sites and Mechanisms of Action
Book title
Cannabinoid Pharmacology
Published in
Advances in Pharmacology, January 2017
DOI 10.1016/bs.apha.2017.05.003
Pubmed ID
Book ISBNs

Katarzyna Starowicz, David P. Finn


The endocannabinoid system, consisting of the cannabinoid1 receptor (CB1R) and cannabinoid2 receptor (CB2R), endogenous cannabinoid ligands (endocannabinoids), and metabolizing enzymes, is present throughout the pain pathways. Endocannabinoids, phytocannabinoids, and synthetic cannabinoid receptor agonists have antinociceptive effects in animal models of acute, inflammatory, and neuropathic pain. CB1R and CB2R located at peripheral, spinal, or supraspinal sites are important targets mediating these antinociceptive effects. The mechanisms underlying the analgesic effects of cannabinoids likely include inhibition of presynaptic neurotransmitter and neuropeptide release, modulation of postsynaptic neuronal excitability, activation of the descending inhibitory pain pathway, and reductions in neuroinflammatory signaling. Strategies to dissociate the psychoactive effects of cannabinoids from their analgesic effects have focused on peripherally restricted CB1R agonists, CB2R agonists, inhibitors of endocannabinoid catabolism or uptake, and modulation of other non-CB1R/non-CB2R targets of cannabinoids including TRPV1, GPR55, and PPARs. The large body of preclinical evidence in support of cannabinoids as potential analgesic agents is supported by clinical studies demonstrating their efficacy across a variety of pain disorders.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 227 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 227 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 42 19%
Researcher 39 17%
Student > Ph. D. Student 24 11%
Student > Master 17 7%
Other 17 7%
Other 37 16%
Unknown 51 22%
Readers by discipline Count As %
Medicine and Dentistry 44 19%
Pharmacology, Toxicology and Pharmaceutical Science 32 14%
Neuroscience 22 10%
Agricultural and Biological Sciences 15 7%
Biochemistry, Genetics and Molecular Biology 14 6%
Other 41 18%
Unknown 59 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2021.
All research outputs
of 19,512,142 outputs
Outputs from Advances in Pharmacology
of 252 outputs
Outputs of similar age
of 285,241 outputs
Outputs of similar age from Advances in Pharmacology
of 1 outputs
Altmetric has tracked 19,512,142 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 252 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 285,241 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them