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Effects of chloroquine on viral infections: an old drug against today's diseases

Overview of attention for article published in Lancet Infectious Diseases, November 2003
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#7 of 4,417)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

news
25 news outlets
blogs
8 blogs
twitter
5078 tweeters
facebook
2 Facebook pages
wikipedia
1 Wikipedia page
reddit
2 Redditors
video
1 video uploader

Citations

dimensions_citation
520 Dimensions

Readers on

mendeley
739 Mendeley
citeulike
1 CiteULike
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Title
Effects of chloroquine on viral infections: an old drug against today's diseases
Published in
Lancet Infectious Diseases, November 2003
DOI 10.1016/s1473-3099(03)00806-5
Pubmed ID
Authors

Adrea Savarino, John R Boelaert, Antonio Cassone, Giancario Majori, Roberto Cauda

Abstract

Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best-studied effects are those against HIV replication, which are being tested in clinical trials. Moreover, chloroquine has immunomodulatory effects, suppressing the production/release of tumour necrosis factor alpha and interleukin 6, which mediate the inflammatory complications of several viral diseases. We review the available information on the effects of chloroquine on viral infections, raising the question of whether this old drug may experience a revival in the clinical management of viral diseases such as AIDS and severe acute respiratory syndrome, which afflict mankind in the era of globalisation.

Twitter Demographics

The data shown below were collected from the profiles of 5,078 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 739 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 <1%
Vietnam 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 734 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 118 16%
Student > Ph. D. Student 92 12%
Student > Bachelor 88 12%
Student > Master 85 12%
Other 46 6%
Other 159 22%
Unknown 151 20%
Readers by discipline Count As %
Medicine and Dentistry 181 24%
Biochemistry, Genetics and Molecular Biology 84 11%
Agricultural and Biological Sciences 65 9%
Pharmacology, Toxicology and Pharmaceutical Science 50 7%
Immunology and Microbiology 42 6%
Other 111 15%
Unknown 206 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 3704. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2020.
All research outputs
#528
of 16,094,294 outputs
Outputs from Lancet Infectious Diseases
#7
of 4,417 outputs
Outputs of similar age
#6
of 290,757 outputs
Outputs of similar age from Lancet Infectious Diseases
#1
of 87 outputs
Altmetric has tracked 16,094,294 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,417 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 54.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,757 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.