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Lectin of Concanavalin A as an anti-hepatoma therapeutic agent

Overview of attention for article published in Journal of Biomedical Science, January 2009
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About this Attention Score

  • Among the highest-scoring outputs from this source (#27 of 195)
  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • Good Attention Score compared to outputs of the same age and source (77th percentile)

Mentioned by

wikipedia
2 Wikipedia pages

Citations

dimensions_citation
85 Dimensions

Readers on

mendeley
144 Mendeley
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Title
Lectin of Concanavalin A as an anti-hepatoma therapeutic agent
Published in
Journal of Biomedical Science, January 2009
DOI 10.1186/1423-0127-16-10
Pubmed ID
Authors

Huan-Yao Lei, Chih-Peng Chang

Abstract

Liver cancer is the predominant cause of cancer mortality in males of Southern China and Taiwan. The current therapy is not satisfactory, and more effective treatments are needed. In the search for new therapies for liver tumor, we found that Concanavalin A (Con A), a lectin from Jack bean seeds, can have a potent anti-hepatoma effect. Con A after binding to the mannose moiety on the cell membrane glycoprotein is internalized preferentially to the mitochondria. An autophagy is triggered which leads to cell death. Con A as a T cell mitogen subsequently activates the immune response in the liver and results in the eradication of the tumor in a murine in situ hepatoma model. The liver tumor nodule formation is inhibited by the CD8+ T cells, and a tumor antigen-specific immune memory is established during the hepatic inflammation. The dual properties (autophagic cytotoxicity and immunomodulation) via the specific carbohydrate binding let Con A exert a potent anti-hepatoma therapeutic effect. The novel mechanism of the Con A anti-hepatoma effect is discussed. The prototype of Con with an anti-hepatoma activity gives support to the search for other natural lectins as anti-cancer compounds.

Mendeley readers

The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 <1%
Ireland 1 <1%
Belgium 1 <1%
Unknown 141 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 31 22%
Student > Master 28 19%
Student > Bachelor 26 18%
Researcher 18 13%
Student > Doctoral Student 11 8%
Other 18 13%
Unknown 12 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 47 33%
Biochemistry, Genetics and Molecular Biology 26 18%
Chemistry 13 9%
Pharmacology, Toxicology and Pharmaceutical Science 10 7%
Medicine and Dentistry 9 6%
Other 28 19%
Unknown 11 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 May 2015.
All research outputs
#817,628
of 3,627,536 outputs
Outputs from Journal of Biomedical Science
#27
of 195 outputs
Outputs of similar age
#24,224
of 93,717 outputs
Outputs of similar age from Journal of Biomedical Science
#2
of 9 outputs
Altmetric has tracked 3,627,536 research outputs across all sources so far. This one has received more attention than most of these and is in the 63rd percentile.
So far Altmetric has tracked 195 research outputs from this source. They receive a mean Attention Score of 3.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,717 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.