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Combination Antibiotic Treatment of Serious Methicillin-Resistant Staphylococcus aureus Infections.

Overview of attention for article published in Seminars in Respiratory & Critical Care Medicine, February 2015
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Mentioned by

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2 tweeters

Citations

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13 Dimensions

Readers on

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15 Mendeley
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Title
Combination Antibiotic Treatment of Serious Methicillin-Resistant Staphylococcus aureus Infections.
Published in
Seminars in Respiratory & Critical Care Medicine, February 2015
DOI 10.1055/s-0034-1396906
Pubmed ID
Authors

J S Davis, S Van Hal, S Y C Tong

Abstract

Outcomes from methicillin-resistant Staphylococcus aureus (MRSA) infections are relatively poor, at least in part due to the limitations of vancomycin (the current standard treatment for MRSA). Combination antibiotic treatment for MRSA infections is an attractive alternative as it could address most of vancomycin's shortcomings, including poor tissue penetration, slow bacterial killing, and emerging resistance in some strains of MRSA. However, the theoretical promise of combination therapy for MRSA infections has not been borne out in most in vitro and animal studies. Multiple combinations have been tested and have been either antagonistic, indifferent, or have had conflicting findings in various studies. This includes combinations of two primarily active agents (such as vancomycin plus daptomycin or linezolid), or the addition of gentamicin or rifampin to either vancomycin or daptomycin. However, hope on this front has come from an unexpected quarter. Although MRSA is by definition inherently resistant to nearly all β-lactam antibiotics, this class of drugs has consistently shown evidence of synergy with either daptomycin or vancomycin in over 25 separate in vitro studies, and a limited number of animal and human observational studies. However, there are currently insufficient data to recommend β-lactam combination therapy in routine clinical use. Results of current and planned randomized controlled trials of this strategy are awaited.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 7%
Brazil 1 7%
United States 1 7%
Argentina 1 7%
Czech Republic 1 7%
Unknown 10 67%

Demographic breakdown

Readers by professional status Count As %
Other 9 60%
Student > Bachelor 9 60%
Student > Ph. D. Student 8 53%
Researcher 6 40%
Student > Postgraduate 5 33%
Other 15 100%
Readers by discipline Count As %
Medicine and Dentistry 30 200%
Unspecified 6 40%
Pharmacology, Toxicology and Pharmaceutical Science 5 33%
Agricultural and Biological Sciences 5 33%
Immunology and Microbiology 3 20%
Other 3 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2015.
All research outputs
#3,320,188
of 5,028,115 outputs
Outputs from Seminars in Respiratory & Critical Care Medicine
#92
of 147 outputs
Outputs of similar age
#114,071
of 179,515 outputs
Outputs of similar age from Seminars in Respiratory & Critical Care Medicine
#6
of 11 outputs
Altmetric has tracked 5,028,115 research outputs across all sources so far. This one is in the 29th percentile – i.e., 29% of other outputs scored the same or lower than it.
So far Altmetric has tracked 147 research outputs from this source. They receive a mean Attention Score of 2.0. This one is in the 30th percentile – i.e., 30% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 179,515 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.