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Mendeley readers
Chapter title |
Study B Cell Antigen Receptor Nano-Scale Organization by In Situ Fab Proximity Ligation Assay
|
---|---|
Chapter number | 12 |
Book title |
B Cell Receptor Signaling
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Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7474-0_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7473-3, 978-1-4939-7474-0
|
Authors |
Kathrin Kläsener, Jianying Yang, Michael Reth |
Abstract |
The B cell antigen receptor (BCR) is found to be non-randomly organized at nano-scale distances on the B cell surface. Studying the organization and relocalization of the BCR is thus likely to provide new clues to understand the activation of the BCR. Indeed, with the in situ Fab proximity ligation assay (Fab-PLA), we now obtain proofs for the dissociation activation of BCRs and start to gain insight into how the relocalization of B cell surface signaling molecules could activate the cells. This chapter describes our methods to study the nano-scale organization of B cell surface receptors and co-receptors with Fab-PLA. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 33% |
Student > Ph. D. Student | 2 | 22% |
Student > Bachelor | 1 | 11% |
Student > Doctoral Student | 1 | 11% |
Unknown | 2 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 22% |
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 11% |
Nursing and Health Professions | 1 | 11% |
Immunology and Microbiology | 1 | 11% |
Other | 0 | 0% |
Unknown | 2 | 22% |