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Use and safety of antiepileptic drugs in psychiatric inpatients—data from the AMSP study

Overview of attention for article published in European Archives of Psychiatry and Clinical Neuroscience, August 2017
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Title
Use and safety of antiepileptic drugs in psychiatric inpatients—data from the AMSP study
Published in
European Archives of Psychiatry and Clinical Neuroscience, August 2017
DOI 10.1007/s00406-017-0827-5
Pubmed ID
Authors

Katrin Druschky, Stefan Bleich, Renate Grohmann, Rolf R. Engel, Alexandra Kleimann, Susanne Stübner, Waldemar Greil, Sermin Toto

Abstract

The psychiatric utilization patterns and risks of antiepileptic drugs (AEDs) were assessed by using data from the drug safety programme Arzneimittelsicherheit in der Psychiatrie over the time period 1993-2013. In a total of 432,215 patients, the main indications for AED use were acute mania, schizoaffective disorder, and schizophrenic and organic psychoses. Valproic acid (VPA) was the most common substance across all of those groups, reaching administration rates of up to 50% since 2005, at which time carbamazepine (CBZ) administration consistently dropped below a rate of 10%. Lamotrigine (LTG) and pregabalin (PGB) increased in relevance after 2005 and 2010, respectively (with administration rates of up to 9%), whereas oxcarbazepine (OXC) was least prevalent (<3%). The mean rates of severe adverse drug reactions (ADRs) ranged from 6 cases per 1000 patients treated (VPA) to 19/1000 (OXC) and were significantly lower with treatment with VPA compared to OXC and CBZ. Hyponatremia was the leading ADR during treatment with OXC; severe allergic skin reactions were most often observed during treatment with CBZ and LTG, and severe oedema was most common during treatment with PGB. Severe hyponatremia induced by OXC was observed significantly more often in female patients than in male patients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 19%
Researcher 3 8%
Student > Ph. D. Student 3 8%
Student > Bachelor 3 8%
Student > Doctoral Student 3 8%
Other 6 17%
Unknown 11 31%
Readers by discipline Count As %
Medicine and Dentistry 11 31%
Pharmacology, Toxicology and Pharmaceutical Science 3 8%
Psychology 3 8%
Neuroscience 2 6%
Environmental Science 1 3%
Other 4 11%
Unknown 12 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2018.
All research outputs
#21,162,249
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#1,094
of 1,243 outputs
Outputs of similar age
#278,682
of 318,626 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#11
of 13 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,243 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 318,626 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.