Title |
Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis
|
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Published in |
Frontiers in Pharmacology, May 2014
|
DOI | 10.3389/fphar.2014.00104 |
Pubmed ID | |
Authors |
Amanda B. Core, Susanna Canali, Jodie L. Babitt |
Abstract |
Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling molecules helped to identify this signaling pathway as a central regulator of the key iron hormone hepcidin in the control of systemic iron homeostasis. This review highlights recent work uncovering the mechanism of action of HJV and the BMP-SMAD signaling pathway in regulating hepcidin expression in the liver, as well as additional studies investigating possible extra-hepatic functions of HJV. This review also explores the interaction between HJV, the BMP-SMAD signaling pathway and other regulators of hepcidin expression in systemic iron balance. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Italy | 1 | <1% |
Unknown | 100 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 17 | 17% |
Student > Bachelor | 12 | 12% |
Researcher | 11 | 11% |
Student > Postgraduate | 8 | 8% |
Student > Master | 8 | 8% |
Other | 16 | 16% |
Unknown | 29 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 20 | 20% |
Biochemistry, Genetics and Molecular Biology | 19 | 19% |
Agricultural and Biological Sciences | 17 | 17% |
Unspecified | 3 | 3% |
Immunology and Microbiology | 3 | 3% |
Other | 7 | 7% |
Unknown | 32 | 32% |