Title |
Malarone treatment failure not associated with previously described mutations in the cytochrome b gene
|
---|---|
Published in |
Malaria Journal, June 2004
|
DOI | 10.1186/1475-2875-3-14 |
Pubmed ID | |
Authors |
Ole Wichmann, Marion Muehlen, Holger Gruss, Frank P Mockenhaupt, Norbert Suttorp, Tomas Jelinek |
Abstract |
Malarone (atovaquone-proguanil) is an effective drug for the treatment and prophylaxis of multidrug-resistant falciparum malaria. However, first cases of resistance have been reported, which are associated with mutations at codon 268 of the parasite's cytochrome b gene. We report the first case of Malarone treatment failure from Central Africa.Drug concentration was well within curative range. Pre- and post-treatment Plasmodium falciparum isolates revealed codon 268 wild-type alleles, and no other mutations of the putative atovaquone-binding domain.These findings illustrate the spread of atovaquone-proguanil-resistance in Africa and question the usefulness of codon 268 as the only target for the surveillance of its emergence. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 1 | 2% |
Unknown | 40 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 24% |
Student > Master | 8 | 20% |
Researcher | 4 | 10% |
Student > Bachelor | 4 | 10% |
Professor > Associate Professor | 3 | 7% |
Other | 7 | 17% |
Unknown | 5 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 24% |
Agricultural and Biological Sciences | 9 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 7% |
Chemistry | 2 | 5% |
Other | 4 | 10% |
Unknown | 6 | 15% |